TSC22D1

TSC22 domain family, member 1, also known as TSC22D1, is a human gene.cite journal | author = Jay P, Ji JW, Marsollier C, Taviaux S, Bergé-Lefranc JL, Berta P | title = Cloning of the human homologue of the TGF beta-stimulated clone 22 gene | journal = Biochem. Biophys. Res. Commun. | volume = 222 | issue = 3 | pages = 821–6 | year = 1996 | month = May | pmid = 8651929 | doi = 10.1006/bbrc.1996.0825 | url = | issn = ] cite journal | author = Ohta S, Shimekake Y, Nagata K | title = Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter | journal = Eur. J. Biochem. | volume = 242 | issue = 3 | pages = 460–6 | year = 1996 | month = December | pmid = 9022669 | doi = 10.1111/j.1432-1033.1996.460rr.x | url = | issn = ]

TSC22 encodes a transcription factor and belongs to the large family of early response genes.cite web | title = Entrez Gene: TSC22D1 TSC22 domain family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8848| accessdate = ]

TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.cite journal | author = Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B | title = Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity | journal = J. Biol. Chem. | volume = 274 | issue = 39 | pages = 27439–47 | year = 1999 | month = September | pmid = 10488076 | doi = 10.1074/jbc.274.39.27439 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shibanuma M, Kuroki T, Nose K |title=Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10219–24 |year= 1992 |pmid= 1587811 |doi=
*cite journal | author=Jay P, Ji JW, Marsollier C, "et al." |title=Cloning of the human homologue of the TGF beta-stimulated clone 22 gene. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 3 |pages= 821–6 |year= 1996 |pmid= 8651929 |doi= 10.1006/bbrc.1996.0825
*cite journal | author=Ohta S, Shimekake Y, Nagata K |title=Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. |journal=Eur. J. Biochem. |volume=242 |issue= 3 |pages= 460–6 |year= 1997 |pmid= 9022669 |doi=
*cite journal | author=Dmitrenko VV, Garifulin OM, Shostak EA, "et al." |title= [The characteristics of different types of mRNA expressed in the human brain] |journal=Tsitol. Genet. |volume=30 |issue= 5 |pages= 41–7 |year= 1997 |pmid= 9026990 |doi=
*cite journal | author=Kester HA, Blanchetot C, den Hertog J, "et al." |title=Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27439–47 |year= 1999 |pmid= 10488076 |doi=
*cite journal | author=Hino S, Kawamata H, Uchida D, "et al." |title=Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 659–64 |year= 2001 |pmid= 11095965 |doi= 10.1006/bbrc.2000.3840
*cite journal | author=Hino S, Kawamata H, Omotehara F, "et al." |title=Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells. |journal=Oncol. Rep. |volume=9 |issue= 2 |pages= 371–4 |year= 2002 |pmid= 11836610 |doi=
*cite journal | author=Hino S, Kawamata H, Omotehara F, "et al." |title=Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 4 |pages= 957–63 |year= 2002 |pmid= 11944908 |doi= 10.1006/bbrc.2002.6776
*cite journal | author=Ohara O, Nagase T, Mitsui G, "et al." |title=Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. |journal=DNA Res. |volume=9 |issue= 2 |pages= 47–57 |year= 2003 |pmid= 12056414 |doi=
*cite journal | author=Gupta RA, Sarraf P, Brockman JA, "et al." |title=Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7431–8 |year= 2003 |pmid= 12468551 |doi= 10.1074/jbc.M208076200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sugawara F, Yamada Y, Watanabe R, "et al." |title=The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy. |journal=Diabetes Res. Clin. Pract. |volume=60 |issue= 3 |pages= 191–7 |year= 2004 |pmid= 12757981 |doi=
*cite journal | author=Uchida D, Omotehara F, Nakashiro K, "et al." |title=Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 4 |pages= 846–54 |year= 2003 |pmid= 12767908 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Choi SJ, Moon JH, Ahn YW, "et al." |title=Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation. |journal=Mol. Cell. Biochem. |volume=271 |issue= 1-2 |pages= 23–8 |year= 2005 |pmid= 15881652 |doi=
*cite journal | author=Rentsch CA, Cecchini MG, Schwaninger R, "et al." |title=Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer. |journal=Int. J. Cancer |volume=118 |issue= 4 |pages= 899–906 |year= 2006 |pmid= 16106424 |doi= 10.1002/ijc.21449
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Lu Y, Kitaura J, Oki T, "et al." |title=Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. |journal=Leukemia |volume=21 |issue= 11 |pages= 2246–57 |year= 2007 |pmid= 17690703 |doi= 10.1038/sj.leu.2404883

External links

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