Cortisone alpha-reductase

Cortisone alpha-reductase
cortisone alpha-reductase
Identifiers
EC number 1.3.1.4
CAS number 9029-09-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cortisone alpha-reductase (EC 1.3.1.4) is an enzyme that catalyzes the chemical reaction

4,5alpha-dihydrocortisone + NADP+ \rightleftharpoons cortisone + NADPH + H+

Thus, the two substrates of this enzyme are 4,5alpha-dihydrocortisone and NADP+, whereas its 3 products are cortisone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4,5alpha-dihydrocortisone:NADP+ Delta4-oxidoreductase. Other names in common use include cortisone Delta4-5alpha-reductase, microsomal steroid reductase (5alpha), Delta4-3-ketosteroid reductase (5alpha), Delta4-3-oxosteroid-5alpha-reductase, NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase, and Delta4-5alpha-reductase.

References

  • McGuire JS, Hollis VW and Tomkins GM (1960). "Some characteristics of the microsomal steroid reductases (5alpha) of rat liver". J. Biol. Chem. 235: 3112–3117. 
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