Acyl-CoA oxidase

In enzymology, an acyl-CoA oxidase (EC number|1.3.3.6) is an enzyme that catalyzes the chemical reaction

:acyl-CoA + O₂ $ightleftharpoons$ trans-2,3-dehydroacyl-CoA + H₂O₂

Thus, the two substrates of this enzyme are acyl-CoA and O₂, whereas its two products are trans-2,3-dehydroacyl-CoA and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is acyl-CoA:oxygen 2-oxidoreductase. Other names in common use include fatty acyl-CoA oxidase, acyl coenzyme A oxidase, and fatty acyl-coenzyme A oxidase. This enzyme participates in 3 metabolic pathways: fatty acid metabolism, polyunsaturated fatty acid biosynthesis, and ppar signaling pathway. It employs one cofactor, FAD.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1IS2, PDB link|1W07, PDB link|2DDH, PDB link|2FON, PDB link|2IX5, and PDB link|2IX6.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|61116-22-1."

Gene Ontology (GO) codes