ACOX1

Acyl-Coenzyme A oxidase 1, palmitoyl, also known as ACOX1, is a human gene.cite web | title = Entrez Gene: ACOX1 acyl-Coenzyme A oxidase 1, palmitoyl| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: ACOX1 acyl-Coenzyme A oxidase 1, palmitoyl| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Seedorf U, Ellinghaus P, Roch Nofer J |title=Sterol carrier protein-2. |journal=Biochim. Biophys. Acta |volume=1486 |issue= 1 |pages= 45–54 |year= 2000 |pmid= 10856712 |doi=
*cite journal | author=Singh H, Brogan M, Johnson D, Poulos A |title=Peroxisomal beta-oxidation of branched chain fatty acids in human skin fibroblasts. |journal=J. Lipid Res. |volume=33 |issue= 11 |pages= 1597–605 |year= 1993 |pmid= 1464743 |doi=
*cite journal | author=Watkins PA, McGuinness MC, Raymond GV, "et al." |title=Distinction between peroxisomal bifunctional enzyme and acyl-CoA oxidase deficiencies. |journal=Ann. Neurol. |volume=38 |issue= 3 |pages= 472–7 |year= 1995 |pmid= 7668838 |doi= 10.1002/ana.410380322
*cite journal | author=Chu R, Varanasi U, Chu S, "et al." |title=Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells. |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4908–15 |year= 1995 |pmid= 7876265 |doi=
*cite journal | author=Fournier B, Saudubray JM, Benichou B, "et al." |title=Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy. |journal=J. Clin. Invest. |volume=94 |issue= 2 |pages= 526–31 |year= 1994 |pmid= 8040306 |doi=
*cite journal | author=Aoyama T, Tsushima K, Souri M, "et al." |title=Molecular cloning and functional expression of a human peroxisomal acyl-coenzyme A oxidase. |journal=Biochem. Biophys. Res. Commun. |volume=198 |issue= 3 |pages= 1113–8 |year= 1994 |pmid= 8117268 |doi= 10.1006/bbrc.1994.1158
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Varanasi U, Chu R, Chu S, "et al." |title=Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 3107–11 |year= 1994 |pmid= 8159712 |doi=
*cite journal | author=Pacot C, Latruffe N |title=Biochemical properties of liver peroxisomes from rat, guinea pig and human species and the influence of hormonal status on rat liver acyl-CoA oxidase mRNA content. |journal=Biochimie |volume=75 |issue= 3-4 |pages= 235–42 |year= 1993 |pmid= 8507686 |doi=
*cite journal | author=Fan CY, Pan J, Chu R, "et al." |title=Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24698–710 |year= 1996 |pmid= 8798738 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Fujiwara C, Imamura A, Hashiguchi N, "et al." |title=Catalase-less peroxisomes. Implication in the milder forms of peroxisome biogenesis disorder. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 37271–7 |year= 2001 |pmid= 10960480 |doi= 10.1074/jbc.M006347200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Suzuki Y, Iai M, Kamei A, "et al." |title=Peroxisomal acyl CoA oxidase deficiency. |journal=J. Pediatr. |volume=140 |issue= 1 |pages= 128–30 |year= 2002 |pmid= 11815777 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704

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