- Mixed function oxidase
Mixed function oxidase is the name of a family of
oxidase enzymes which each of the two atoms ofoxygen in O2 is used for a different function in the reaction. [MeshName|Mixed+Function+Oxygenases]Oxidase is a general name for enzymes that catalyze oxidations in which molecular oxygen is the electron acceptor but oxygen atoms do not appear in the oxidized product. Often oxygen is either reduced to
water (cytochrome oxidase of themitochondrial electron transfer chain ) orhydrogen peroxide (dehydrogenation of fatty acyl-CoA inperoxisome s). Most of the oxidases areflavoprotein s.The name "mixed-function oxidase" indicates that the enzyme oxidizes two different substrate simultaneously. Desaturation of fatty acyl-CoA in vertebrates is an example of the mixed-function oxidase reaction. In the process, saturated fatty acyl-CoA and
NADPH are oxidized by molecular oxygen (O2) to produce monounsaturated fatty acyl-CoA, NADP+ and 2 moleculaes of water.Reaction
The mixed-function oxidase reaction proceeds as follows:
AH + BH2 + O2 --> AOH + B + H2O
References
Wikimedia Foundation. 2010.