S-(hydroxymethyl)glutathione dehydrogenase

In enzymology, a S-(hydroxymethyl)glutathione dehydrogenase (EC number|1.1.1.284) is an enzyme that catalyzes the chemical reaction

:S-(hydroxymethyl)glutathione + NAD(P)+ $ightleftharpoons$ S-formylglutathione + NAD(P)H + H⁺

The 3 substrates of this enzyme are S-(hydroxymethyl)glutathione, NAD⁺, and NADP⁺, whereas its 4 products are S-formylglutathione, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is S-(hydroxymethyl)glutathione:NAD+ oxidoreductase. Other names in common use include NAD-linked formaldehyde dehydrogenase (incorrect), formaldehyde dehydrogenase (incorrect), formic dehydrogenase (incorrect), class III alcohol dehydrogenase, ADH3, &chi, -ADH, FDH (incorrect), formaldehyde dehydrogenase (glutathione) (incorrect), GS-FDH (incorrect), glutathione-dependent formaldehyde dehydrogenase (incorrect), NAD-dependent formaldehyde dehydrogenase, GD-FALDH, and NAD- and glutathione-dependent formaldehyde dehydrogenase. This enzyme participates in methane metabolism.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2FZE and PDB link|2FZW.

References

* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
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External links

Gene Ontology (GO) codes