ADH5

Alcohol dehydrogenase 5 (class III), chi polypeptide, also known as ADH5, is a human gene.cite web | title = Entrez Gene: ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=128| accessdate = ]

PBB_Summary
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summary_text = This gene encodes glutathione-dependent formaldehyde dehydrogenase or class III alcohol dehydrogenase chi subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class III alcohol dehydrogenase is a homodimer composed of 2 chi subunits. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis.cite web | title = Entrez Gene: ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=128| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hur MW, Edenberg HJ |title=Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. |journal=Gene |volume=121 |issue= 2 |pages= 305–11 |year= 1992 |pmid= 1446828 |doi=
*cite journal | author=Iborra FJ, Renau-Piqueras J, Portoles M, "et al." |title=Immunocytochemical and biochemical demonstration of formaldhyde dehydrogenase (class III alcohol dehydrogenase) in the nucleus. |journal=J. Histochem. Cytochem. |volume=40 |issue= 12 |pages= 1865–78 |year= 1992 |pmid= 1453005 |doi=
*cite journal | author=Giri PR, Krug JF, Kozak C, "et al." |title=Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=164 |issue= 1 |pages= 453–60 |year= 1989 |pmid= 2679557 |doi=
*cite journal | author=Sharma CP, Fox EA, Holmquist B, "et al." |title=cDNA sequence of human class III alcohol dehydrogenase. |journal=Biochem. Biophys. Res. Commun. |volume=164 |issue= 2 |pages= 631–7 |year= 1989 |pmid= 2818582 |doi=
*cite journal | author=Beisswenger TB, Holmquist B, Vallee BL |title=chi-ADH is the sole alcohol dehydrogenase isozyme of mammalian brains: implications and inferences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 24 |pages= 8369–73 |year= 1986 |pmid= 2934732 |doi=
*cite journal | author=Dafeldecker WP, Vallee BL |title=Organ-specific human alcohol dehydrogenase: isolation and characterization of isozymes from testis. |journal=Biochem. Biophys. Res. Commun. |volume=134 |issue= 3 |pages= 1056–63 |year= 1986 |pmid= 2936344 |doi=
*cite journal | author=Kaiser R, Holmquist B, Hempel J, "et al." |title=Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes. |journal=Biochemistry |volume=27 |issue= 4 |pages= 1132–40 |year= 1988 |pmid= 3365377 |doi=
*cite journal | author=Adinolfi A, Adinolfi M, Hopkinson DA |title=Immunological and biochemical characterization of the human alcohol dehydrogenase chi-ADH isozyme. |journal=Ann. Hum. Genet. |volume=48 |issue= Pt 1 |pages= 1–10 |year= 1984 |pmid= 6424546 |doi=
*cite journal | author=Khokha AM, Voronov PP, Zimatkin SM |title= [Immunoenzyme and immunohistochemical analysis of class III alcohol dehydrogenase from human testis] |journal=Biokhimiia |volume=59 |issue= 7 |pages= 997–1002 |year= 1994 |pmid= 7948423 |doi=
*cite journal | author=Engeland K, Höög JO, Holmquist B, "et al." |title=Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 6 |pages= 2491–4 |year= 1993 |pmid= 8460164 |doi=
*cite journal | author=Holmquist B, Moulis JM, Engeland K, Vallee BL |title=Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. |journal=Biochemistry |volume=32 |issue= 19 |pages= 5139–44 |year= 1993 |pmid= 8494891 |doi=
*cite journal | author=Engeland K, Maret W |title=Extrahepatic, differential expression of four classes of human alcohol dehydrogenase. |journal=Biochem. Biophys. Res. Commun. |volume=193 |issue= 1 |pages= 47–53 |year= 1993 |pmid= 8503936 |doi= 10.1006/bbrc.1993.1588
*cite journal | author=Yang ZN, Bosron WF, Hurley TD |title=Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase. |journal=J. Mol. Biol. |volume=265 |issue= 3 |pages= 330–43 |year= 1997 |pmid= 9018047 |doi= 10.1006/jmbi.1996.0731
*cite journal | author=Mori O, Haseba T, Kameyama K, "et al." |title=Histological distribution of class III alcohol dehydrogenase in human brain. |journal=Brain Res. |volume=852 |issue= 1 |pages= 186–90 |year= 2000 |pmid= 10661511 |doi=
*cite journal | author=Sanghani PC, Stone CL, Ray BD, "et al." |title=Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase. |journal=Biochemistry |volume=39 |issue= 35 |pages= 10720–9 |year= 2000 |pmid= 10978156 |doi=
*cite journal | author=Lee DK, Suh D, Edenberg HJ, Hur MW |title=POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26761–8 |year= 2002 |pmid= 12004059 |doi= 10.1074/jbc.M202078200
*cite journal | author=Jelski W, Chrostek L, Szmitkowski M, Laszewicz W |title=Activity of class I, II, III, and IV alcohol dehydrogenase isoenzymes in human gastric mucosa. |journal=Dig. Dis. Sci. |volume=47 |issue= 7 |pages= 1554–7 |year= 2002 |pmid= 12141816 |doi=
*cite journal | author=Sanghani PC, Robinson H, Bosron WF, Hurley TD |title=Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes. |journal=Biochemistry |volume=41 |issue= 35 |pages= 10778–86 |year= 2002 |pmid= 12196016 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sanghani PC, Bosron WF, Hurley TD |title=Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation. |journal=Biochemistry |volume=41 |issue= 51 |pages= 15189–94 |year= 2003 |pmid= 12484756 |doi=

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