Mannitol 2-dehydrogenase (NADP+)

Mannitol 2-dehydrogenase (NADP+)
mannitol 2-dehydrogenase (NADP+)
Identifiers
EC number 1.1.1.138
CAS number 37250-68-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a mannitol 2-dehydrogenase (NADP+) (EC 1.1.1.138) is an enzyme that catalyzes the chemical reaction

D-mannitol + NADP+ \rightleftharpoons D-fructose + NADPH + H+

Thus, the two substrates of this enzyme are D-mannitol and NADP+, whereas its 3 products are D-fructose, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol:NADP+ 2-oxidoreductase. This enzyme is also called mannitol 2-dehydrogenase (NADP+). This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1H5Q.

References

  • EDMUNDOWICZ JM, WRISTON JC Jr (1963). "MANNITOL DEHYDROGENASE FROM AGARICUS CAMPESTRIS". J. Biol. Chem. 238: 3539–41. PMID 14109183. 
  • Strobel GA and Kosuge T (1965). "Polyol metabolism in Diplodia viticola Desm". Arch. Biochem. Biophys. 109 (3): 622–626. doi:10.1016/0003-9861(65)90409-1. 
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