Mannitol dehydrogenase

mannitol dehydrogenase
Identifiers
EC number	1.1.1.255
CAS number	144941-29-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a mannitol dehydrogenase (EC 1.1.1.255) is an enzyme that catalyzes the chemical reaction

D-mannitol + NAD⁺ $\rightleftharpoons$ D-mannose + NADH + H⁺

Thus, the two substrates of this enzyme are D-mannitol and NAD⁺, whereas its 3 products are D-mannose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is mannitol:NAD+ 1-oxidoreductase. Other names in common use include MTD, and NAD+-dependent mannitol dehydrogenase.

References

• Stoop JM, Pharr DM (1992). "Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots". Arch. Biochem. Biophys. 298 (2): 612–9. doi:10.1016/0003-9861(92)90456-7. PMID 1416989. 
• Stoop JM, Williamson JD, Conkling MA, Pharr DM (1995). "Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures". Plant. Physiol. 108 (3): 1219–25. doi:10.1104/pp.108.3.1219. PMC 157476. PMID 7630943. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=157476. 
• Williamson JD, Stoop JM, Massel MO, Conkling MA, Pharr DM (1995). "Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3". Proc. Natl. Acad. Sci. U. S. A. 92 (16): 7148–52. doi:10.1073/pnas.92.16.7148. PMC 41296. PMID 7638158. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41296. 
• Stoop, JMH, Chilton WS and Pharr DM (1996). "Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery". Phytochemistry 43 (6): 1145–1150. doi:10.1016/S0031-9422(96)00423-2. 

See also

• D-Mannitol

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