UGT2B7

UGT2B7

protein
Name=UDP glucuronosyltransferase 2 family, polypeptide B7
caption=


width=
HGNCid=12554
Symbol=UGT2B7
AltSymbols=
EntrezGene=7364
OMIM=600068
RefSeq=NM_001074
UniProt=P16662
PDB=
ECnumber=
Chromosome=4
Arm=q
Band=13
LocusSupplementaryData=

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain.

This enzyme is located on the endoplasmic reticulum and nuclear membranes of cells. Its function is to catalyse the conjugation of a wide variety of lipophilic aglycon substrates with glucuronic acid, using uridine diphosphate glucuronic acid.

UGT2B7 is the major enzyme isoform for the metabolism of morphine to the main metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). [ cite journal |author=Coffman B, Rios G, King C, Tephly T |title=Human UGT2B7 catalyzes morphine glucuronidation |journal=Drug Metab. Dispos. |volume=25 |issue=1 |pages=1–4 |year=1997 |pmid=9010622 |url=http://dmd.aspetjournals.org/cgi/content/abstract/25/1/1]

References

External links

* http://www.pharmgkb.org/do/serve?objId=PA361
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