UGT2B15

UDP glucuronosyltransferase 2 family, polypeptide B15, also known as UGT2B15, is a human gene.cite web | title = Entrez Gene: UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7366| accessdate = ]

PBB_Summary
section_title =
summary_text = The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067). [supplied by OMIM] cite web | title = Entrez Gene: UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7366| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Coffman BL, Tephly TR, Irshaid YM, "et al." |title=Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase. |journal=Arch. Biochem. Biophys. |volume=281 |issue= 1 |pages= 170–5 |year= 1990 |pmid= 2116769 |doi=
*cite journal | author=Irshaid YM, Tephly TR |title=Isolation and purification of two human liver UDP-glucuronosyltransferases. |journal=Mol. Pharmacol. |volume=31 |issue= 1 |pages= 27–34 |year= 1987 |pmid= 3100939 |doi=
*cite journal | author=Green MD, Clarke DJ, Oturu EM, "et al." |title=Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. |journal=Arch. Biochem. Biophys. |volume=322 |issue= 2 |pages= 460–8 |year= 1995 |pmid= 7574722 |doi= 10.1006/abbi.1995.1489
*cite journal | author=Green MD, Oturu EM, Tephly TR |title=Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. |journal=Drug Metab. Dispos. |volume=22 |issue= 5 |pages= 799–805 |year= 1995 |pmid= 7835232 |doi=
*cite journal | author=Monaghan G, Clarke DJ, Povey S, "et al." |title=Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13. |journal=Genomics |volume=23 |issue= 2 |pages= 496–9 |year= 1995 |pmid= 7835904 |doi= 10.1006/geno.1994.1531
*cite journal | author=Chen F, Ritter JK, Wang MG, "et al." |title=Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms. |journal=Biochemistry |volume=32 |issue= 40 |pages= 10648–57 |year= 1993 |pmid= 8399210 |doi=
*cite journal | author=Guillemette C, Lévesque E, Beaulieu M, "et al." |title=Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells. |journal=Endocrinology |volume=138 |issue= 7 |pages= 2998–3005 |year= 1997 |pmid= 9202245 |doi=
*cite journal | author=Lévesque E, Beaulieu M, Green MD, "et al." |title=Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene. |journal=Pharmacogenetics |volume=7 |issue= 4 |pages= 317–25 |year= 1997 |pmid= 9295060 |doi=
*cite journal | author=Strassburg CP, Strassburg A, Nguyen N, "et al." |title=Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. |journal=Biochem. J. |volume=338 ( Pt 2) |issue= |pages= 489–98 |year= 1999 |pmid= 10024527 |doi=
*cite journal | author=Tchernof A, Lévesque E, Beaulieu M, "et al." |title=Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method. |journal=Clin. Endocrinol. (Oxf) |volume=50 |issue= 5 |pages= 637–42 |year= 1999 |pmid= 10468930 |doi=
*cite journal | author=Strassburg CP, Kneip S, Topp J, "et al." |title=Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36164–71 |year= 2000 |pmid= 10748067 |doi= 10.1074/jbc.M002180200
*cite journal | author=Gsur A, Preyer M, Haidinger G, "et al." |title=A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=11 |issue= 5 |pages= 497–8 |year= 2002 |pmid= 12010866 |doi=
*cite journal | author=Iida A, Saito S, Sekine A, "et al." |title=Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8. |journal=J. Hum. Genet. |volume=47 |issue= 10 |pages= 505–10 |year= 2002 |pmid= 12376738 |doi= 10.1007/s100380200075
*cite journal | author=Court MH, Duan SX, Guillemette C, "et al." |title=Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9. |journal=Drug Metab. Dispos. |volume=30 |issue= 11 |pages= 1257–65 |year= 2003 |pmid= 12386133 |doi=
*cite journal | author=Kanaya J, Takashima M, Koh E, Namiki M |title=Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression. |journal=Asian J. Androl. |volume=5 |issue= 1 |pages= 9–13 |year= 2003 |pmid= 12646996 |doi=
*cite journal | author=Zhang JY, Zhan J, Cook CS, "et al." |title=Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism. |journal=Drug Metab. Dispos. |volume=31 |issue= 5 |pages= 652–8 |year= 2003 |pmid= 12695355 |doi=
*cite journal | author=Tomboc M, Witchel SF |title=Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism. |journal=J. Pediatr. Endocrinol. Metab. |volume=16 |issue= 5 |pages= 719–26 |year= 2003 |pmid= 12880121 |doi=
*cite journal | author=Court MH, Hao Q, Krishnaswamy S, "et al." |title=UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver. |journal=J. Pharmacol. Exp. Ther. |volume=310 |issue= 2 |pages= 656–65 |year= 2005 |pmid= 15044558 |doi= 10.1124/jpet.104.067660
*cite journal | author=Toide K, Umeda S, Yamazaki H, "et al." |title=A major genotype in UDP-glucuronosyltransferase 2B15. |journal=Drug Metab. Pharmacokinet. |volume=17 |issue= 2 |pages= 164–6 |year= 2005 |pmid= 15618667 |doi=
*cite journal | author=Chouinard S, Pelletier G, Bélanger A, Barbier O |title=Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium. |journal=Endocr. Res. |volume=30 |issue= 4 |pages= 717–25 |year= 2005 |pmid= 15666817 |doi=

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