- Glucuronosyltransferase
Protein
Name=PAGENAME
caption=
Symbol=UGT1A1
AltSymbols=
HGNCid=12530
Chromosome=2
Arm=q
Band=37
LocusSupplementaryData=
ECnumber=2.4.1.17
OMIM=191740
EntrezGene=54658
RefSeq=NM_000463
UniProt=P22309
PDB=Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a
glycosyltransferase (EC number|2.4.1.17) that catalyzes theglucuronidation reaction. [cite journal |author=King C, Rios G, Green M, Tephly T |title=UDP-glucuronosyltransferases |journal=Curr Drug Metab |volume=1 |issue=2 |pages=143–61 |year=2000 |pmid=11465080 |doi=10.2174/1389200003339171]"Alternative names:"
*glucuronyltransferaseFunction
This reaction involves the addition of sugars to lipids and other apolar xenobiotics and is an important step in the body's elimination of foreign substances (such as drugs and medications) as well as endogenous substances (including endogenous toxins). UGT is present in humans, other animals, plants, and bacteria.
The glucuronidation reaction consists of the transfer of the
glucuronosyl group fromuridine 5'-diphospho-glucuronic acid (UDPGA) to substrate molecules that contain oxygen, nitrogen, sulfur or carboxyl functional groups. [cite journal |author=Bock K, Köhle C |title=UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects |journal=Methods Enzymol |volume=400 |issue= |pages=57–75 |year= |pmid=16399343] The resultingglucuronide is more polar (e.g. hydrophilic) and more easily excreted than the substrate molecule. The product solubility in blood is increased allowing it to be eliminated from the body by thekidney s.Diseases
A deficiency in the bilirubin specific form of glucuronosyltransferase is thought to be the cause of
Gilbert's syndrome , which is characterized byhyperbilirubinemia .It is also associated with
Crigler-Najjar syndrome , a more serious disorder where the enzyme's activity is either completely absent (Crigler-Najjar syndrome type I) or less than 10% of normal (type II).Genes
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B3GAT1 ,B3GAT2 ,B3GAT3 *
UGT1A1 ,UGT1A3 ,UGT1A4 ,UGT1A5 ,UGT1A6 ,UGT1A7 ,UGT1A8 ,UGT1A9 ,UGT1A10 *
UGT2A1 ,UGT2A2 ,UGT2A3 ,UGT2B4 ,UGT2B7 ,UGT2B10 ,UGT2B11 ,UGT2B15 ,UGT2B17 ,UGT2B28 External links
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References
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