RAD18

RAD18 homolog (S. cerevisiae), also known as RAD18, is a human gene.cite web | title = Entrez Gene: RAD18 RAD18 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56852| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is a ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.cite web | title = Entrez Gene: RAD18 RAD18 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56852| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Tateishi S, Sakuraba Y, Masuyama S, "et al." |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7927–32 |year= 2000 |pmid= 10884424 |doi=
*cite journal | author=Xin H, Lin W, Sumanasekera W, "et al." |title=The human RAD18 gene product interacts with HHR6A and HHR6B. |journal=Nucleic Acids Res. |volume=28 |issue= 14 |pages= 2847–54 |year= 2000 |pmid= 10908344 |doi=
*cite journal | author=Mulder LC, Chakrabarti LA, Muesing MA |title=Interaction of HIV-1 integrase with DNA repair protein hRad18. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27489–93 |year= 2002 |pmid= 12016221 |doi= 10.1074/jbc. M203061200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nikiforov AA, Sasina LK, Svetlova MP, "et al." |title=Early immobilization of nuclease FEN1 and accumulation of hRAD18 protein at stalled DNA replication forks in mammalian cells. |journal=Dokl. Biochem. Biophys. |volume=389 |issue= |pages= 122–5 |year= 2004 |pmid= 12856420 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Watanabe K, Tateishi S, Kawasuji M, "et al." |title=Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. |journal=EMBO J. |volume=23 |issue= 19 |pages= 3886–96 |year= 2005 |pmid= 15359278 |doi= 10.1038/sj.emboj.7600383
*cite journal | author=Nikiforov A, Svetlova M, Solovjeva L, "et al." |title=DNA damage-induced accumulation of Rad18 protein at stalled replication forks in mammalian cells involves upstream protein phosphorylation. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 3 |pages= 831–7 |year= 2004 |pmid= 15381075 |doi= 10.1016/j.bbrc.2004.08.165
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Miyase S, Tateishi S, Watanabe K, "et al." |title=Differential regulation of Rad18 through Rad6-dependent mono- and polyubiquitination. |journal=J. Biol. Chem. |volume=280 |issue= 1 |pages= 515–24 |year= 2005 |pmid= 15509568 |doi= 10.1074/jbc. M409219200
*cite journal | author=Masuyama S, Tateishi S, Yomogida K, "et al." |title=Regulated expression and dynamic changes in subnuclear localization of mammalian Rad18 under normal and genotoxic conditions. |journal=Genes Cells |volume=10 |issue= 8 |pages= 753–62 |year= 2005 |pmid= 16098139 |doi= 10.1111/j.1365-2443.2005.00874.x
*cite journal | author=Nousiainen M, Silljé HH, Sauer G, "et al." |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103
*cite journal | author=Bi X, Barkley LR, Slater DM, "et al." |title=Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest. |journal=Mol. Cell. Biol. |volume=26 |issue= 9 |pages= 3527–40 |year= 2006 |pmid= 16611994 |doi= 10.1128/MCB.26.9.3527-3540.2006
*cite journal | author=Lloyd AG, Tateishi S, Bieniasz PD, "et al." |title=Effect of DNA repair protein Rad18 on viral infection. |journal=PLoS Pathog. |volume=2 |issue= 5 |pages= e40 |year= 2006 |pmid= 16710452 |doi= 10.1371/journal.ppat.0020040
*cite journal | author=Yuasa MS, Masutani C, Hirano A, "et al." |title=A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. |journal=Genes Cells |volume=11 |issue= 7 |pages= 731–44 |year= 2006 |pmid= 16824193 |doi= 10.1111/j.1365-2443.2006.00974.x
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, "in vivo", and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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