David Chilton Phillips

David Chilton Phillips, Baron Phillips of Ellesmere, KBE, FRS (7 March 1924 - 23 February 1999)^[1] is considered to be a founding father of the now expanding field of structural biology and was an influential figure in science and government. Among scientists, he will be remembered as the first person ever to determine in atomic detail the structure of the enzyme lysozyme, which he did in the Davy Faraday Research Laboratories of the Royal Institution in London in 1965. Lysozyme, which was discovered in 1922 by Alexander Fleming,^[2] is found in tear drops, nasal mucus, gastric secretions and egg white. Lysozyme exhibits some antibacterial activity so that the discovery of its structure and mode of action were key scientific objectives. David Phillips solved the structure of lysozyme and also explained the mechanism of its action in destroying certain bacteria by a brilliant application of the technique of X-ray crystallography, a technique to which he had been introduced as a PhD student at the University in Cardiff, and to which he later made major instrumental contributions.

David Chilton Phillips, the son of a tailor and Methodist preacher, was born in Ellesmere, Shropshire which gave rise to his title Baron Phillips of Ellesmere. He was educated at Oswestry Boy's High School and then at the University College of South Wales and Monmouth where he studied physics, electrical engineering, and mathematics. His degree was interrupted between 1944 and 1947 for services in the Navy as a radar officer on HMS Illustrious. He returned to Cardiff to complete his degree and subsequently undertook postgraduate studies with Professor Arthur J. C. Wilson, a noted X-ray crystal physicist. After a brief postdoctoral period at the National Research Council in Ottawa (1951–55) he joined the Royal Institution. In 1968 he became the Professor of Molecular Biophysics in the Department of Zoology at the University of Oxford where he remained until his retirement in 1985. During that time he became a Fellow of the Royal Society and then its Biological Secretary from 1976 to 1983.

David was made Knight Bachelor in 1979, invested as Knight Commander of the Order of the British Empire (KBE) in 1989, and appointed in 1994 as a Life Peer as Baron Phillips of Ellesmere. In the House of Lords, he chaired the select committee on Science and Technology and he is credited with getting Parliament onto the World Wide Web.

Lord Phillips died of cancer, on 23 February 1999.

References

1. ^ Johnson, L. N. (2000). "David Chilton Phillips, Lord Phillips of Ellesmere, K.B.E. 7 March 1924 -- 23 February 1999: Elected F.R.S. 1967". Biographical Memoirs of Fellows of the Royal Society 46: 377. doi:10.1098/rsbm.1999.0092.  edit
2. ^ Fleming, Alexander (May 1922). "On a Remarkable Bacteriolytic Element Found in Tissues and Secretions". Proceedings of the Royal Society. B 93 (653): 306–317. doi:10.1098/rspb.1922.0023. ISSN 0962-8452. JSTOR 80959. 

• Cardiff Scientific Society by John Griffith (Chair) and Bruce Etherington (Vice Chair)

Academic offices
Preceded by Max Ferdinand Perutz	Fullerian Professor of Physiology 1979–1985	Succeeded by John Bertrand Gurdon

Persondata
Name	Phillips, David Chilton
Alternative names
Short description	Biophysicist and structural biologist
Date of birth	7 March 1924
Place of birth	Ellesmere, Shropshire, England
Date of death	23 February 1999
Place of death