Myoglobinuria

Myoglobinuria
Classification and external resources
Urine from a person with rhabdomyolysis showing the characteristic brown discoloration as a result of myoglobinuria
ICD-10	R82.1
ICD-9	791.3
DiseasesDB	23059
eMedicine	ped/1535
MeSH	D009212

Model of helical domains in myoglobin.

Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or muscle destruction. Myoglobin is present in muscle cells as a reserve of oxygen.

Causes

Trauma, vascular problems, venoms, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys.

Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of renal problems, it can occlude the renal filtration system leading to acute tubular necrosis and acute renal insufficiency.

Other causes of myoglobinuria include:

• McArdle's disease
• Phosphofructokinase deficiency^[1]
• Carnitine palmitoyltransferase II deficiency

Diagnosis

After centrifuging, the serum of myoglobinuria is clear, where the serum of hemoglobinuria after centrifuge is pink.^{[citation needed]}

External links

• Overview on the Neuromuscular disease center website.

References

1. ^ Toscano A, Musumeci O (October 2007). "Tarui disease and distal glycogenoses: clinical and genetic update". Acta Myol 26 (2): 105–7. PMC 2949577. PMID 18421897. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2949577.