NADPH:quinone reductase

NADPH:quinone reductase
Identifiers
EC number	1.6.5.5
CAS number	9032-20-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a NADPH:quinone reductase (EC 1.6.5.5) is an enzyme that catalyzes the chemical reaction

NADPH + H⁺ + quinone $\rightleftharpoons$ NADP⁺ + semiquinone

The 3 substrates of this enzyme are NADPH, H⁺, and quinone, whereas its two products are NADP⁺ and semiquinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. The systematic name of this enzyme class is NADPH:quinone oxidoreductase. This enzyme is also called NADPH2:quinone reductase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1IYZ, 1IZ0, and 1YB5.

References

• Rao PV, Krishna CM, Zigler JS Jr (1992). "Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase". J. Biol. Chem. 267 (1): 96–102. PMID 1370456. 

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