Dichlorotetrakis(dimethyl sulfoxide)ruthenium(II)

Dichlorotetrakis(dimethyl sulfoxide) ruthenium (II)
Systematic name Ruthenium, dichlorotetrakis(sulfinylbis(methane))- (9CI)
Other names Tetrakis(dimethylsulfoxide)dichlororuthenium(II), Dichlorotetrakis(methylsulfoxide)ruthenium, Dichlorotetrakis(sulfinylbis(methane))ruthenium
Identifiers
CAS number	11070-19-2
Properties
Molecular formula	C8H24Cl2O4RuS4
Molar mass	484.51 g/mol
Appearance	Various shades of yellow crystals
Solubility in water	water miscible
Solubility	nitromethane, chloroform, dichloromethane
Structure
Coordination geometry	octahedral coordinate
Y sulfoxide)ruthenium(II) (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Dichlorotetrakis(dimethyl sulfoxide) ruthenium(II) describes coordination compounds with the formula RuCl₂(dmso)₄, where DMSO is dimethylsulfoxide. These complexes illustrate linkage isomerism for the ligand DMSO.^[1] In these complexes, two chloride anions and four molecules of dmso are coordinated to a central ruthenium (II) core.

Structure

RuCl₂(dmso)₄ has been isolated as two isomers, but each is an octahedral coordination compound. The ruthenium adopts a +2 oxidation state, and the compounds follows the 18 electron rule.

The two isomers are cis, fac-RuCl₂(dmso-S)₃(dmso-O) and trans, mer-RuCl₂(dmso-S)₄. The trans, mer configuration is kinetically favored, but thermodynamically unstable with respect to the cis isomer. Cis and trans refer to the relative positions of the chloride ligands. The fac/mer describes the binding of the dmso ligands. The notation dmso-S/O refers to the atom through which the dmso molecule is coordinated to the ruthenium center. Thus, dmso-S means that the dmso ligand coordinates through the sulfur atom, whereas dmso-O coordinates through the oxygen atom.

cis,fac isomer	trans,mer isomer

Synthesis

The complexes were first prepared by heating DMSO solutions of ruthenium trichloride under hydrogen atmosphere.^[2] An alternative procedure has been developed which avoids hydrogen gas.^[3] Ruthenium-dmso complexes inhibit or kill tumors. Trans-RuCl₄(dmso-S)L are being tested for their ^[4]

Applications

These and related dmso-containing ruthenium compounds have attracted attention due to their cancer therapeutic properties.^[4]

References

1. ^ Enzo Alessio (2004). "Synthesis and reactivity of Ru-, Os-, Rh-, and Ir-halide-sulfoxide compounds". Chem. Rev. 104: 4203–4242. doi:10.1021/cr0307291. 
2. ^ B. R. James, E. Ochiai, and G.I. Rempel (1971). "Ruthenium (II) halide dimethylsulphoxide complexes from hydrogenation reactions". Inorganic and Nuclear Chemistry Letters 7: 781. doi:10.1016/0020-1650(71)80091-0. 
3. ^ I. Bratsos and E. Alessio (2010). "Ruthenium(II) chloro complexes of dimethylsulfoxide". Inorganic Syntheses 35: 148–152. 
4. ^ ^{a b} Bratsos, I; Serli, B; Zangranko, E; Katsaros, N; Alessio, E. (2007). "Replacement of chlorides with dicarboxylate ligands in anticancer active Ru(II)-DMSO compounds: A new strategy that might lead to improved activity". Inorg. Chem. 46: 975–992. doi:10.1021/ic0613964. PMID 17257042.