Dichlorotetrakis(dimethyl sulfoxide) ruthenium (II)

chembox new
Name = Dichlorotetrakis(dimethyl sulfoxide) ruthenium (II)
ImageFile = RuCl2-dmso4.png SystematicName = Ruthenium, dichlorotetrakis(sulfinylbis(methane))- (9CI)
OtherNames = Tetrakis(dimethylsulfoxide)dichlororuthenium(II), Dichlorotetrakis(methylsulfoxide)ruthenium, Dichlorotetrakis(sulfinylbis(methane))ruthenium
Section1 = Chembox Identifiers
CASNo = [11070-19-2]
Section2 = Chembox Properties
Formula = C₈H₂₄Cl₂O₄RuS₄
MolarMass = 484.51 g/mol
Appearance = Various shades of yellow crystals
Solubility = water miscible
SolubleOther = nitromethane, chloroform, dichloromethane
Section3 = Chembox Structure
Coordination = octahedral coordinate

Dichlorotetrakis(dimethyl sulfoxide) ruthenium(II) describes coordination compounds with the formula RuCl₂(dmso)₄, where DMSO is dimethylsulfoxide. These complexes illustrate linkage isomerism for the ligand DMSO. [Enzo Alessio. Synthesis and reactivity of Ru-, Os-, Rh-, and Ir-halide-sulfoxide compounds. Chemical Reviews 2004, volume 104, pp 4203-4242.] In these complexes, two chloride anions and four molecules of dmso are coordinated to a central ruthenium (II) core.

tructure

RuCl₂(dmso)₄ has been isolated as two isomers, but each is an octahedral coordination compound. The ruthenium adopts a +2 oxidation state, and the compounds follows the 18 electron rule.

The two isomers are "cis, fac"-RuCl₂(dmso-S)₃(dmso-O) and "trans, mer"-RuCl₂(dmso-S)₄. The "trans, mer" configuration is kinetically favored, but thermodynamically unstable with respect to the cis isomer. "Cis" and "trans" refer to the relative positions of the chloride ligands. The "fac"/"mer" describes the binding of the dmso ligands. The notation dmso-S/O refers to the atom through which the dmso molecule is coordinated to the ruthenium center. Thus, dmso-S means that the dmso ligand coordinates through the sulfur atom, whereas dmso-O coordinates through the oxygen atom.

ynthesis

The complexes were first prepared by heating DMSO solutions of ruthenium trichloride.B. R. James, E. Ochiai, and G.I. Rempel, Inorganic and Nuclear Chemistry Letters, 7, 781 (1971).] Ruthenium-dmso complexes inhibit or kill tumors. "Trans"-RuCl₄(dmso-S)L are being tested for their

Applications

These and related dmso-containing ruthenium compounds have attracted attention due to their cancer therapeutic properties.Bratsos, I; Serli, B; Zangranko, E; Katsaros, N; Alessio, E. Replacement of chlorides with dicarboxylate ligands in anticancer active Ru(II)-DMSO compounds: A new strategy that might lead to improved activity” Inorganic Chemistry 2007, volume 46, pp 975-992.]

References