NPTX2

Neuronal pentraxin II
Identifiers
Symbols	NPTX2; NARP; NP-II; NP2
External IDs	OMIM: 600750 MGI: 1858209 HomoloGene: 1892 GeneCards: NPTX2 Gene
Gene Ontology Molecular function • molecular_function • sugar binding • metal ion binding Cellular component • cellular_component • extracellular region Biological process • synaptic transmission Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4885	53324
Ensembl	ENSG00000106236	ENSMUSG00000059991
UniProt	P47972	Q3UYB9
RefSeq (mRNA)	NM_002523	NM_016789.3
RefSeq (protein)	NP_002514	NP_058069.1
Location (UCSC)	Chr 7: 98.25 – 98.26 Mb	Chr 5: 145.31 – 145.32 Mb
PubMed search	[1]	[2]

Neuronal pentraxin-2 is a protein that in humans is encoded by the NPTX2 gene.^[1][2]

Function

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.^[2]

Clinical significance

Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.^[2]

References

1. ^ Hsu YC, Perin MS (Feb 1996). "Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization". Genomics 28 (2): 220–7. doi:10.1006/geno.1995.1134. PMID 8530029. 
2. ^ ^{a b c} "Entrez Gene: NPTX2 neuronal pentraxin II". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4885. 

Further reading

• Park JK, Ryu JK, Lee KH, et al. (2007). "Quantitative analysis of NPTX2 hypermethylation is a promising molecular diagnostic marker for pancreatic cancer.". Pancreas 35 (3): e9–15. doi:10.1097/MPA.0b013e318153fa42. PMID 17895837. 
• Marui T, Koishi S, Funatogawa I, et al. (2007). "No association between the neuronal pentraxin II gene polymorphism and autism.". Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (4): 940–3. doi:10.1016/j.pnpbp.2007.02.016. PMID 17408830. 
• Poulsen TT, Pedersen N, Perin MS, et al. (2006). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin.". Lung Cancer 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068. 
• Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49". J. Biol. Chem. 272 (34): 21488–94. doi:10.1074/jbc.272.34.21488. PMID 9261167. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.