AMPA

AMPA

Chembox new
ImageFile = AMPA.png ImageSize =
IUPACName = alpha-amino-3-hydroxy
-5-methyl-4-isoxazole
propionic acid
OtherNames =
Section1 = Chembox Identifiers
CASNo = 77521-29-0
PubChem = 1221
SMILES =
ChemSpiderID = 1184
MeSHName = AMPA
Section2 = Chembox Properties
Formula = C7H10N2O4
MolarMass = 186.165
Appearance =
Density =
MeltingPt =
BoilingPt =
Section3 = Chembox Hazards
Solubility =
MainHazards =
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Autoignition =

AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) is a specific agonist for the AMPA receptor.

AMPA mimics the effect of glutamate. There are two broad categories of glutamate receptors: ionotropic receptors and metabotropic receptors. Ionotropic receptors are ligand gated channels whose agonists include AMPA, Kainate and NMDA. Metabotropic receptors are G-protein coupled receptors and are separated into individual classes. In the synapse these receptors are believed to serve very different purposes, most of the functions linking to the CNS. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions. AMPA generates fast excitatory postsynaptic potentials (EPSP).

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