- NPTXR
-
Neuronal pentraxin receptor Identifiers Symbols NPTXR; NPR External IDs OMIM: 609474 MGI: 1920590 HomoloGene: 8620 GeneCards: NPTXR Gene Gene Ontology Molecular function • receptor activity
• pentraxin receptor activity
• protein complex binding
• metal ion bindingCellular component • extracellular space
• plasma membrane
• integral to membraneBiological process • response to hydrogen peroxide Sources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 23467 73340 Ensembl ENSG00000221890 ENSMUSG00000022421 UniProt O95502 Q99J85 RefSeq (mRNA) NM_014293 NM_030689.4 RefSeq (protein) NP_055108 NP_109614.2 Location (UCSC) Chr 22:
39.21 – 39.24 MbChr 15:
79.62 – 79.64 MbPubMed search [1] [2] Neuronal pentraxin receptor is a protein that in humans is encoded by the NPTXR gene.[1][2]
This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat protein pentraxin is thought to mediate neuronal uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for human and mouse, based on strong sequence conservation amongst these species.[2]
See also
- NPTX2, Neuronal pentraxin II
References
- ^ Andersson KB, Florholmen G, Winer LH, Tonnessen T, Christensen G (Feb 2006). "Regulation of neuronal type genes in congestive heart failure rats". Acta Physiol (Oxf) 186 (1): 17–27. doi:10.1111/j.1748-1716.2005.01503.x. PMID 16497176.
- ^ a b "Entrez Gene: NPTXR neuronal pentraxin receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23467.
Further reading
- Poulsen TT, Pedersen N, Perin MS, et al. (2006). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin.". Lung Cancer 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2.". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49.". J. Biol. Chem. 272 (34): 21488–94. doi:10.1074/jbc.272.34.21488. PMID 9261167.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
This protein-related article is a stub. You can help Wikipedia by expanding it.
