DGKQ

Diacylglycerol kinase, theta 110kDa
Identifiers
Symbols	DGKQ; DAGK; DAGK4; DAGK7
External IDs	OMIM: 601207 MGI: 102918 HomoloGene: 20352 GeneCards: DGKQ Gene
EC number	2.7.1.107
Gene Ontology Molecular function • nucleotide binding • diacylglycerol kinase activity • diacylglycerol kinase activity • protein binding • ATP binding • transferase activity • kinase binding • activating transcription factor binding • phospholipase binding • metal ion binding Cellular component • nucleus • cytoplasm • cytosol • cytoskeleton • plasma membrane • plasma membrane • nuclear speck Biological process • G-protein coupled receptor protein signaling pathway • activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway • blood coagulation • platelet activation • response to ATP • regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor • intracellular signal transduction • thrombin receptor signaling pathway • protein kinase C signaling cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1609	110524
Ensembl	ENSG00000145214	ENSMUSG00000004815
UniProt	P52824	n/a
RefSeq (mRNA)	NM_001347	NM_199011.1
RefSeq (protein)	NP_001338	NP_950176.1
Location (UCSC)	Chr 4: 0.95 – 0.98 Mb	Chr 5: 109.08 – 109.1 Mb
PubMed search	[1]	[2]

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.^[1][2][3]

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.^[3]

Interactions

DGKQ has been shown to interact with RHOA.^[4]

References

1. ^ Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502. 
2. ^ Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683. 
3. ^ ^{a b} "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1609. 
4. ^ Houssa, B; de Widt J, Kranenburg O, Moolenaar W H, van Blitterswijk W J (Mar. 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. (UNITED STATES) 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731. 

Further reading

• Sakane F, Kanoh H (1998). "Molecules in focus: diacylglycerol kinase". Int. J. Biochem. Cell Biol. 29 (10): 1139–43. doi:10.1016/S1357-2725(97)00037-X. PMID 9438377. 
• Li D, Urs AN, Allegood J et al. (2008). "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17". Mol. Cell. Biol. 27 (19): 6669–85. doi:10.1128/MCB.00355-07. PMC 2099220. PMID 17664281. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2099220. 
• van Baal J, de Widt J, Divecha N, van Blitterswijk WJ (2005). "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C". J. Biol. Chem. 280 (11): 9870–8. doi:10.1074/jbc.M409301200. PMID 15632189. 
• Tabellini G, Bortul R, Santi S et al. (2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus". Exp. Cell Res. 287 (1): 143–54. doi:10.1016/S0014-4827(03)00115-0. PMID 12799190. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Houssa B, de Widt J, Kranenburg O et al. (1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. PMID 10066731. 
• Sakane F, Imai S, Kai M et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J. Biol. Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.