DAP (gene)

DAP (gene)
Death-associated protein
Identifiers
Symbols DAP; MGC99796
External IDs OMIM600954 MGI1918190 HomoloGene3235 GeneCards: DAP Gene
RNA expression pattern
PBB GE DAP 201095 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1611 223453
Ensembl ENSG00000112977 ENSMUSG00000039168
UniProt P51397 Q3U706
RefSeq (mRNA) NM_004394 NM_146057.3
RefSeq (protein) NP_004385 NP_666169.1
Location (UCSC) Chr 5:
10.68 – 10.76 Mb
Chr 15:
31.15 – 31.2 Mb
PubMed search [1] [2]

Death-associated protein 1 is a protein that in humans is encoded by the DAP gene.[1][2][3]

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.[3]

References

  1. ^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096. 
  2. ^ Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev 9 (1): 15–30. doi:10.1101/gad.9.1.15. PMID 7828849. 
  3. ^ a b "Entrez Gene: DAP death-associated protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1611. 

Further reading


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