PAFAH1B3

Platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDB rendering based on 1bwp.
Available structures PDB 1bwp, 1bwq, 1bwr, 1es9, 1fxw, 1wab
Identifiers
Symbols	PAFAH1B3; FLJ44990; PAFAHG
External IDs	OMIM: 603074 MGI: 108414 HomoloGene: 1933 GeneCards: PAFAH1B3 Gene
EC number	3.1.1.47
Gene Ontology Molecular function • 1-alkyl-2-acetylglycerophosphocholine esterase activity • protein binding • hydrolase activity Cellular component • cytoplasm Biological process • lipid metabolic process • nervous system development • lipid catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5050	18476
Ensembl	ENSG00000079462	ENSMUSG00000005447
UniProt	Q15102	Q3TJC2
RefSeq (mRNA)	NM_001145939.1	NM_008776.2
RefSeq (protein)	NP_001139411.1	NP_032802.1
Location (UCSC)	Chr 19: 42.8 – 42.81 Mb	Chr 7: 26.08 – 26.08 Mb
PubMed search	[1]	[2]

Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the PAFAH1B3 gene.^[1][2]

Interactions

PAFAH1B3 has been shown to interact with PAFAH1B1^[3] and LNX1.^[4]

See also

• PAFAH1B1
• PAFAH1B2

References

1. ^ Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Oct 1995). "cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues". Biochem Biophys Res Commun 214 (1): 180–7. doi:10.1006/bbrc.1995.2272. PMID 7669037. 
2. ^ "Entrez Gene: PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5050. 
3. ^ Sweeney, K J; Clark G D, Prokscha A, Dobyns W B, Eichele G (Apr. 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mech. Dev. (IRELAND) 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. ISSN 0925-4773. PMID 10727864. 
4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading

• Moro F, Arrigo G, Fogli A, et al. (1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively.". Genomics 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049. 
• Sweeney KJ, Clark GD, Prokscha A, et al. (2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development.". Mech. Dev. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864. 
• Sheffield PJ, McMullen TW, Li J, et al. (2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib.". Protein Eng. 14 (7): 513–9. doi:10.1093/protein/14.7.513. PMID 11522926. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Saito Y, Doi K, Yamagishi N, et al. (2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems.". Biochem. Biophys. Res. Commun. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID 14733918. 
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.