- PAFAH1B2
-
Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDB rendering based on 1fxw.Available structures PDB 1fxw, 1vyh Identifiers Symbols PAFAH1B2; External IDs OMIM: 602508 MGI: 108415 HomoloGene: 1932 GeneCards: PAFAH1B2 Gene EC number 3.1.1.47 Gene Ontology Molecular function • 1-alkyl-2-acetylglycerophosphocholine esterase activity
• hydrolase activity, acting on ester bondsCellular component • cytoplasm Biological process • lipid metabolic process
• lipid catabolic processSources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5049 18475 Ensembl ENSG00000168092 ENSMUSG00000003131 UniProt P68402 Q6PKE6 RefSeq (mRNA) NM_001184746.1 NM_008775.3 RefSeq (protein) NP_001171675.1 NP_032801.2 Location (UCSC) Chr 11:
117.01 – 117.05 MbChr 9:
45.77 – 45.79 MbPubMed search [1] [2] Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene.[1][2][3]
Contents
Interactions
PAFAH1B2 has been shown to interact with PAFAH1B1.[4]
See also
References
- ^ Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Jun 1997). "Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I)". Biochem Biophys Res Commun 233 (1): 10–3. doi:10.1006/bbrc.1997.6383. PMID 9144386.
- ^ Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Sep 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049.
- ^ "Entrez Gene: PAFAH1B2 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5049.
- ^ Sweeney, K J; Clark G D, Prokscha A, Dobyns W B, Eichele G (Apr. 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mech. Dev. (IRELAND) 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. ISSN 0925-4773. PMID 10727864.
Further reading
- Albrecht U, Abu-Issa R, Rätz B, et al. (1997). "Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor.". Dev. Biol. 180 (2): 579–93. doi:10.1006/dbio.1996.0330. PMID 8954729.
- Sweeney KJ, Clark GD, Prokscha A, et al. (2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development.". Mech. Dev. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.
- Sheffield PJ, McMullen TW, Li J, et al. (2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib.". Protein Eng. 14 (7): 513–9. doi:10.1093/protein/14.7.513. PMID 11522926.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Hasstedt SJ, Scott BT, Rosendaal FR, et al. (2007). "Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample.". Thromb. Haemost. 98 (3): 587–92. PMID 17849047.
PDB gallery Categories:- Human proteins
- Chromosome 11 gene stubs
Wikimedia Foundation. 2010.