NAPSA

Napsin A aspartic peptidase
Identifiers
Symbols	NAPSA; KAP; Kdap; NAP1; NAPA; SNAPA
External IDs	OMIM: 605631 MGI: 109365 HomoloGene: 68418 GeneCards: NAPSA Gene
Gene Ontology Molecular function • aspartic-type endopeptidase activity • peptidase activity Cellular component • extracellular region Biological process • proteolysis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9476	16541
Ensembl	ENSG00000131400	ENSMUSG00000002204
UniProt	O96009	Q3TDT8
RefSeq (mRNA)	NM_004851	NM_008437.1
RefSeq (protein)	NP_004842	NP_032463.1
Location (UCSC)	Chr 19: 50.86 – 50.87 Mb	Chr 7: 51.83 – 51.84 Mb
PubMed search	[1]	[2]

Napsin-A is a protein that in humans is encoded by the NAPSA gene.^[1]

The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.^[1]

References

1. ^ ^{a b} "Entrez Gene: NAPSA napsin A aspartic peptidase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9476. 

Further reading

• Koelsch G, Mares M, Metcalf P, Fusek M (1994). "Multiple functions of pro-parts of aspartic proteinase zymogens.". FEBS Lett. 343 (1): 6–10. doi:10.1016/0014-5793(94)80596-2. PMID 8163018. 
• Blundell TL, Guruprasad K, Albert A, et al. (1998). "The aspartic proteinases. An historical overview.". Adv. Exp. Med. Biol. 436: 1–13. PMID 9561193. 
• Tatnell PJ, Powell DJ, Hill J, et al. (1999). "Napsins: new human aspartic proteinases. Distinction between two closely related genes.". FEBS Lett. 441 (1): 43–8. doi:10.1016/S0014-5793(98)01522-1. PMID 9877162. 
• Chuman Y, Bergman A, Ueno T, et al. (2000). "Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas.". FEBS Lett. 462 (1-2): 129–34. doi:10.1016/S0014-5793(99)01493-3. PMID 10580105. 
• Schauer-Vukasinovic V, Bur D, Kling D, et al. (2000). "Human napsin A: expression, immunochemical detection, and tissue localization.". FEBS Lett. 462 (1-2): 135–9. doi:10.1016/S0014-5793(99)01458-1. PMID 10580106. 
• Yan R, Bienkowski MJ, Shuck ME, et al. (1999). "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.". Nature 402 (6761): 533–7. doi:10.1038/990107. PMID 10591213. 
• Cook M, Bühling F, Ansorge S, et al. (2002). "Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells.". Biochim. Biophys. Acta 1577 (1): 10–6. PMID 12151090. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ueno T, Linder S, Elmberger G (2004). "Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma.". Br. J. Cancer 88 (8): 1229–33. doi:10.1038/sj.bjc.6600879. PMC 2747556. PMID 12698189. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2747556. 
• Brasch F, Ochs M, Kahne T, et al. (2004). "Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung.". J. Biol. Chem. 278 (49): 49006–14. doi:10.1074/jbc.M306844200. PMID 13129928. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex.". Nat. Cell Biol. 6 (4): 319–27. doi:10.1038/ncb1105. PMID 15048123.