NCK interacting protein with SH3 domain
External IDs OMIM606671 MGI1931834 HomoloGene9514 GeneCards: NCKIPSD Gene
Species Human Mouse
Entrez 51517 80987
Ensembl ENSG00000213672 ENSMUSG00000032598
UniProt Q9NZQ3 Q3UYF3
RefSeq (mRNA) NM_016453.2 NM_030729.4
RefSeq (protein) NP_057537.1 NP_109654.2
Location (UCSC) Chr 3:
48.7 – 48.72 Mb
Chr 9:
108.71 – 108.72 Mb
PubMed search [1] [2]

NCK-interacting protein with SH3 domain is a protein that in humans is encoded by the NCKIPSD gene.[1][2][3]

The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified.[3]


NCKIPSD has been shown to interact with Grb2[4][5] and NCK1.[6]


  1. ^ Sano K, Hayakawa A, Piao JH, Kosaka Y, Nakamura H (Feb 2000). "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23)". Blood 95 (3): 1066–8. PMID 10648423. 
  2. ^ de Bernard M, Moschioni M, Napolitani G, Rappuoli R, Montecucco C (Feb 2000). "The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein". EMBO J 19 (1): 48–56. doi:10.1093/emboj/19.1.48. PMC 1171776. PMID 10619843. 
  3. ^ a b "Entrez Gene: NCKIPSD NCK interacting protein with SH3 domain". 
  4. ^ Satoh, S; Tominaga T (Oct. 2001). "mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation". J. Biol. Chem. (United States) 276 (42): 39290–4. doi:10.1074/jbc.M107026200. ISSN 0021-9258. PMID 11509578. 
  5. ^ Fukuoka, M; Suetsugu S, Miki H, Fukami K, Endo T, Takenawa T (Feb. 2001). "A Novel Neural Wiskott-Aldrich Syndrome Protein (N-Wasp) Binding Protein, Wish, Induces Arp2/3 Complex Activation Independent of Cdc42". J. Cell Biol. (United States) 152 (3): 471–82. doi:10.1083/jcb.152.3.471. ISSN 0021-9525. PMC 2196001. PMID 11157975. 
  6. ^ Lim, C S; Park E S, Kim D J, Song Y H, Eom S H, Chun J S, Kim J H, Kim J K, Park D, Song W K (Apr. 2001). "SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adaptor protein that is developmentally regulated during cardiac myocyte differentiation". J. Biol. Chem. (United States) 276 (16): 12871–8. doi:10.1074/jbc.M009411200. ISSN 0021-9258. PMID 11278500. 

Further reading