NOL3

Nucleolar protein 3 (apoptosis repressor with CARD domain)
Identifiers
Symbols	NOL3; ARC; FLJ35304; MYP; NOP; NOP30
External IDs	OMIM: 605235 MGI: 1925938 HomoloGene: 31208 GeneCards: NOL3 Gene
Gene Ontology Molecular function • RNA binding • protein binding • identical protein binding Cellular component • intracellular • nucleus • nucleolus • cytoplasm • cytosol Biological process • mRNA processing • anti-apoptosis • RNA splicing • regulation of apoptosis
Orthologs
Species	Human	Mouse
Entrez	8996	78688
Ensembl	ENSG00000140939	ENSMUSG00000014776
UniProt	n/a	Q53YU5
RefSeq (mRNA)	NM_001185057.1	NM_030152.4
RefSeq (protein)	NP_001171986.1	NP_084428.1
Location (UCSC)	Chr 16: 67.2 – 67.21 Mb	Chr 8: 107.8 – 107.81 Mb
PubMed search	[1]	[2]

Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene.^[1][2]

Interactions

NOL3 has been shown to interact with SFRS9^[3] and Caspase 8.^[1]

References

1. ^ ^{a b} Koseki T, Inohara N, Chen S, Nunez G (Jun 1998). "ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases". Proc Natl Acad Sci U S A 95 (9): 5156–60. doi:10.1073/pnas.95.9.5156. PMC 20230. PMID 9560245. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20230. 
2. ^ "Entrez Gene: NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8996. 
3. ^ Stoss, O; Schwaiger F W, Cooper T A, Stamm S (Apr. 1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. (UNITED STATES) 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. ISSN 0021-9258. PMID 10196175. 

Further reading

• Stoss O, Schwaiger FW, Cooper TA, Stamm S (1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. PMID 10196175. 
• Irie Y, Yamagata K, Gan Y (2000). "Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells". J. Biol. Chem. 275 (4): 2647–53. doi:10.1074/jbc.275.4.2647. PMID 10644725. 
• Li PF, Li J, Müller EC (2002). "Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC". Mol. Cell 10 (2): 247–58. doi:10.1016/S1097-2765(02)00600-7. PMID 12191471. 
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ekhterae D, Platoshyn O, Zhang S (2003). "Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents". Am. J. Physiol., Cell Physiol. 284 (6): C1405–10. doi:10.1152/ajpcell.00279.2002. PMID 12734105. 
• Nam YJ, Mani K, Ashton AW (2004). "Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions". Mol. Cell 15 (6): 901–12. doi:10.1016/j.molcel.2004.08.020. PMID 15383280. 
• Gerhard DS, Wagner L, Feingold EA (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Jo DG, Jun JI, Chang JW (2004). "Calcium Binding of ARC Mediates Regulation of Caspase 8 and Cell Death". Mol. Cell. Biol. 24 (22): 9763–70. doi:10.1128/MCB.24.22.9763-9770.2004. PMC 525473. PMID 15509781. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=525473. 
• Wang M, Qanungo S, Crow MT (2005). "Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei". FEBS Lett. 579 (11): 2411–5. doi:10.1016/j.febslet.2005.03.040. PMID 15848180. 
• Mercier I, Vuolo M, Madan R (2005). "ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance". Cell Death Differ. 12 (6): 682–6. doi:10.1038/sj.cdd.4401631. PMID 15861191. 
• Rual JF, Venkatesan K, Hao T (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Donath S, Li P, Willenbockel C (2006). "Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress". Circulation 113 (9): 1203–12. doi:10.1161/CIRCULATIONAHA.105.576785. PMID 16505176. 
• Nam YJ, Mani K, Wu L (2007). "The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant". J. Biol. Chem. 282 (8): 5522–8. doi:10.1074/jbc.M609186200. PMID 17142452. 
• Ewing RM, Chu P, Elisma F (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 

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