ODF1

ODF1
Outer dense fiber of sperm tails 1
Identifiers
Symbols ODF1; CT133; HSPB10; MGC129928; MGC129929; ODF; ODF2; ODF27; ODFP; ODFPG; ODFPGA; ODFPGB; RT7; SODF
External IDs OMIM182878 MGI97424 HomoloGene7456 GeneCards: ODF1 Gene
RNA expression pattern
PBB GE ODF1 214485 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4956 18285
Ensembl ENSG00000155087 ENSMUSG00000061923
UniProt Q14990 Q61999
RefSeq (mRNA) NM_024410 NM_008757.3
RefSeq (protein) NP_077721 NP_032783.2
Location (UCSC) Chr 8:
103.56 – 103.57 Mb
Chr 15:
38.15 – 38.16 Mb
PubMed search [1] [2]

Outer dense fiber protein 1 is a protein that in humans is encoded by the ODF1 gene.[1][2]

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein.[2]

References

  1. ^ Gastmann O, Burfeind P, Gunther E, Hameister H, Szpirer C, Hoyer-Fender S (Mar 1994). "Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene". Mol Reprod Dev 36 (4): 407–418. doi:10.1002/mrd.1080360402. PMID 8305202. 
  2. ^ a b "Entrez Gene: ODF1 outer dense fiber of sperm tails 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4956. 

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