NPAT (gene)

Nuclear protein, ataxia-telangiectasia locus
Identifiers
Symbols	NPAT; E14; E14/NPAT; p220
External IDs	OMIM: 601448 MGI: 107605 HomoloGene: 1888 GeneCards: NPAT Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • transcription coactivator activity • transcription corepressor activity • protein binding • protein C-terminus binding • protein N-terminus binding Cellular component • nucleus • Cajal body • nuclear part Biological process • regulation of transcription involved in G1/S phase of mitotic cell cycle • transcription, DNA-dependent • cell cycle • regulation of gene expression • positive regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4863	244879
Ensembl	ENSG00000149308	ENSMUSG00000033054
UniProt	Q14207	n/a
RefSeq (mRNA)	NM_002519	NM_001081152.1
RefSeq (protein)	NP_002510	NP_001074621.1
Location (UCSC)	Chr 11: 108.03 – 108.09 Mb	Chr 9: 53.35 – 53.38 Mb
PubMed search	[1]	[2]

Protein NPAT is a protein that in humans is encoded by the NPAT gene.^[1][2]

Interactions

NPAT (gene) has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase^[3] and POU2F1.^[3]

References

1. ^ Imai T, Sugawara T, Nishiyama A, Shimada R, Ohki R, Seki N, Sagara M, Ito H, Yamauchi M, Hori T (Sep 1997). "The structure and organization of the human NPAT gene". Genomics 42 (3): 388–92. doi:10.1006/geno.1997.4769. PMID 9205109. 
2. ^ "Entrez Gene: NPAT nuclear protein, ataxia-telangiectasia locus". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4863. 
3. ^ ^{a b} Zheng, Lei; Roeder Robert G, Luo Yan (Jul. 2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component". Cell (United States) 114 (2): 255–66. doi:10.1016/S0092-8674(03)00552-X. ISSN 0092-8674. PMID 12887926. 

Further reading

• Imai T, Yamauchi M, Seki N, et al. (1996). "Identification and characterization of a new gene physically linked to the ATM gene.". Genome Res. 6 (5): 439–47. doi:10.1101/gr.6.5.439. PMID 8743993. 
• Byrd PJ, McConville CM, Cooper P, et al. (1996). "Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia.". Hum. Mol. Genet. 5 (1): 145–9. doi:10.1093/hmg/5.1.145. PMID 8789452. 
• Byrd PJ, Cooper PR, Stankovic T, et al. (1997). "A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies.". Hum. Mol. Genet. 5 (11): 1785–91. doi:10.1093/hmg/5.11.1785. PMID 8923007. 
• Zhao J, Dynlacht B, Imai T, et al. (1998). "Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.". Genes Dev. 12 (4): 456–61. doi:10.1101/gad.12.4.456. PMC 316526. PMID 9472014. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316526. 
• Zhao J, Kennedy BK, Lawrence BD, et al. (2000). "NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.". Genes Dev. 14 (18): 2283–97. doi:10.1101/gad.827700. PMC 316937. PMID 10995386. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316937. 
• Sagara M, Takeda E, Nishiyama A, et al. (2004). "Characterization of functional regions for nuclear localization of NPAT.". J. Biochem. 132 (6): 875–9. PMID 12473189. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gao G, Bracken AP, Burkard K, et al. (2003). "NPAT expression is regulated by E2F and is essential for cell cycle progression.". Mol. Cell. Biol. 23 (8): 2821–33. doi:10.1128/MCB.23.8.2821-2833.2003. PMC 152552. PMID 12665581. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152552. 
• Wei Y, Jin J, Harper JW (2003). "The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.". Mol. Cell. Biol. 23 (10): 3669–80. doi:10.1128/MCB.23.10.3669-3680.2003. PMC 164767. PMID 12724424. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164767. 
• Zheng L, Roeder RG, Luo Y (2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.". Cell 114 (2): 255–66. doi:10.1016/S0092-8674(03)00552-X. PMID 12887926. 
• Ye X, Wei Y, Nalepa G, Harper JW (2003). "The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.". Mol. Cell. Biol. 23 (23): 8586–600. doi:10.1128/MCB.23.23.8586-8600.2003. PMC 262656. PMID 14612403. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=262656. 
• Wang A, Ikura T, Eto K, Ota MS (2005). "Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry.". Biochem. Biophys. Res. Commun. 325 (4): 1509–16. doi:10.1016/j.bbrc.2004.10.198. PMID 15555599. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Kalla C, Scheuermann MO, Kube I, et al. (2007). "Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B.". Eur. J. Cancer 43 (8): 1328–35. doi:10.1016/j.ejca.2007.02.005. PMID 17449237. 
• Medina R, van der Deen M, Miele-Chamberland A, et al. (2007). "The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes.". Cancer Res. 67 (21): 10334–42. doi:10.1158/0008-5472.CAN-07-1560. PMID 17974976.