NHP2L1

NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
PDB rendering based on 1e7k.
Available structures PDB 1E7K, 2JNB, 2OZB
Identifiers
Symbols	NHP2L1; 15.5K; FA-1; FA1; NHPX; OTK27; SNRNP15-5; SNU13; SPAG12; SSFA1
External IDs	OMIM: 601304 HomoloGene: 3672 GeneCards: NHP2L1 Gene
Gene Ontology Molecular function • RNA binding • protein binding • snoRNA binding Cellular component • nucleus • nucleoplasm • spliceosomal complex • nucleolus • box C/D snoRNP complex Biological process • nuclear mRNA splicing, via spliceosome • RNA splicing • gene expression • ribosome biogenesis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4809	100040177
Ensembl	ENSG00000100138	n/a
UniProt	P55769	n/a
RefSeq (mRNA)	NM_001003796.1	n/a
RefSeq (protein)	NP_001003796.1	n/a
Location (UCSC)	Chr 22: 42.07 – 42.09 Mb	n/a
PubMed search	[1]	[2]

NHP2-like protein 1 is a protein that in humans is encoded by the NHP2L1 gene.^[1][2]

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.^[2]

Interactions

NHP2L1 has been shown to interact with RAD17.^[3]

References

1. ^ Saito H, Fujiwara T, Shin S, Okui K, Nakamura Y (Jan 1997). "Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2". Cytogenet Cell Genet 72 (2–3): 191–3. doi:10.1159/000134186. PMID 8978773. 
2. ^ ^{a b} "Entrez Gene: NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4809. 
3. ^ Chang, M S; Sasaki H, Campbell M S, Kraeft S K, Sutherland R, Yang C Y, Liu Y, Auclair D, Hao L, Sonoda H, Ferland L H, Chen L B (Dec. 1999). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation". J. Biol. Chem. (UNITED STATES) 274 (51): 36544–9. doi:10.1074/jbc.274.51.36544. ISSN 0021-9258. PMID 10593953. 

Further reading

• Nottrott S, Hartmuth K, Fabrizio P, et al. (2000). "Functional interaction of a novel 15.5kD [U4/U6.U5 tri-snRNP protein with the 5' stem-loop of U4 snRNA"]. EMBO J. 18 (21): 6119–33. doi:10.1093/emboj/18.21.6119. PMC 1171676. PMID 10545122. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171676. 
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
• Chang MS, Sasaki H, Campbell MS, et al. (2000). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation". J. Biol. Chem. 274 (51): 36544–9. doi:10.1074/jbc.274.51.36544. PMID 10593953. 
• Vidovic I, Nottrott S, Hartmuth K, et al. (2001). "Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment". Mol. Cell 6 (6): 1331–42. doi:10.1016/S1097-2765(00)00131-3. PMID 11163207. 
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. 
• Leung AK, Lamond AI (2002). "In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles". J. Cell Biol. 157 (4): 615–29. doi:10.1083/jcb.200201120. PMC 2173864. PMID 12011111. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173864. 
• Watkins NJ, Dickmanns A, Lührmann R (2003). "Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP". Mol. Cell. Biol. 22 (23): 8342–52. doi:10.1128/MCB.22.23.8342-8352.2002. PMC 134055. PMID 12417735. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=134055. 
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133617. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545604. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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