RAD17

RAD17 homolog (S. pombe), also known as RAD17, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported.cite web | title = Entrez Gene: RAD17 RAD17 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5884| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Li L, Li HS, Pauza CD, "et al." |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923–34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370
*cite journal | author=al-Khodairy F, Carr AM |title=DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. |journal=EMBO J. |volume=11 |issue= 4 |pages= 1343–50 |year= 1992 |pmid= 1563350 |doi=
*cite journal | author=Mossi R, Jónsson ZO, Allen BL, "et al." |title=Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1769–76 |year= 1997 |pmid= 8999859 |doi=
*cite journal | author=Parker AE, Van de Weyer I, Laus MC, "et al." |title=Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18340–6 |year= 1998 |pmid= 9660800 |doi=
*cite journal | author=Bao S, Shen X, Shen K, "et al." |title=The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. |journal=Cell Growth Differ. |volume=9 |issue= 12 |pages= 961–7 |year= 1999 |pmid= 9869296 |doi=
*cite journal | author=Dean FB, Lian L, O'Donnell M |title=cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. |journal=Genomics |volume=54 |issue= 3 |pages= 424–36 |year= 1999 |pmid= 9878245 |doi= 10.1006/geno.1998.5587
*cite journal | author=Bluyssen HA, Naus NC, van Os RI, "et al." |title=Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene. |journal=Genomics |volume=55 |issue= 2 |pages= 219–28 |year= 1999 |pmid= 9933569 |doi= 10.1006/geno.1998.5642
*cite journal | author=Li L, Peterson CA, Kanter-Smoler G, "et al." |title=hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation. |journal=Oncogene |volume=18 |issue= 9 |pages= 1689–99 |year= 1999 |pmid= 10208430 |doi= 10.1038/sj.onc.1202469
*cite journal | author=Bao S, Chang MS, Auclair D, "et al." |title=HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma. |journal=Cancer Res. |volume=59 |issue= 9 |pages= 2023–8 |year= 1999 |pmid= 10232579 |doi=
*cite journal | author=von Deimling F, Scharf JM, Liehr T, "et al." |title=Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma. |journal=Hum. Genet. |volume=105 |issue= 1-2 |pages= 17–27 |year= 1999 |pmid= 10480350 |doi=
*cite journal | author=Chang MS, Sasaki H, Campbell MS, "et al." |title=HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36544–9 |year= 2000 |pmid= 10593953 |doi=
*cite journal | author=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538–43 |year= 2000 |pmid= 10608806 |doi=
*cite journal | author=Burtelow MA, Kaufmann SH, Karnitz LM |title=Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26343–8 |year= 2000 |pmid= 10852904 |doi= 10.1074/jbc.M001244200
*cite journal | author=Rauen M, Burtelow MA, Dufault VM, Karnitz LM |title=The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29767–71 |year= 2000 |pmid= 10884395 |doi= 10.1074/jbc.M005782200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Bao S, Tibbetts RS, Brumbaugh KM, "et al." |title=ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. |journal=Nature |volume=411 |issue= 6840 |pages= 969–74 |year= 2001 |pmid= 11418864 |doi= 10.1038/35082110
*cite journal | author=Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A |title=Purification and characterization of human DNA damage checkpoint Rad complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 20 |pages= 11236–41 |year= 2001 |pmid= 11572977 |doi= 10.1073/pnas.201373498
*cite journal | author=Chen MS, Higashikubo R, Laszlo A, Roti Roti J |title=Multiple alternative splicing forms of human RAD17 and their differential response to ionizing radiation. |journal=Gene |volume=277 |issue= 1-2 |pages= 145–52 |year= 2001 |pmid= 11602352 |doi=
*cite journal | author=Post S, Weng YC, Cimprich K, "et al." |title=Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 23 |pages= 13102–7 |year= 2001 |pmid= 11687627 |doi= 10.1073/pnas.231364598

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