RAD9A

RAD9 homolog A (S. pombe), also known as RAD9A, is a human gene.

PBB_Summary
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summary_text = This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene.cite web | title = Entrez Gene: RAD9A RAD9 homolog A (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5883| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lieberman HB |title=Rad9, an evolutionarily conserved gene with multiple functions for preserving genomic integrity. |journal=J. Cell. Biochem. |volume=97 |issue= 4 |pages= 690–7 |year= 2006 |pmid= 16365875 |doi= 10.1002/jcb.20759
*cite journal | author=Lieberman HB, Hopkins KM, Nass M, "et al." |title=A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 13890–5 |year= 1997 |pmid= 8943031 |doi=
*cite journal | author=Volkmer E, Karnitz LM |title=Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 567–70 |year= 1999 |pmid= 9872989 |doi=
*cite journal | author=St Onge RP, Udell CM, Casselman R, Davey S |title=The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. |journal=Mol. Biol. Cell |volume=10 |issue= 6 |pages= 1985–95 |year= 1999 |pmid= 10359610 |doi=
*cite journal | author=Komatsu K, Miyashita T, Hang H, "et al." |title=Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis. |journal=Nat. Cell Biol. |volume=2 |issue= 1 |pages= 1–6 |year= 2000 |pmid= 10620799 |doi= 10.1038/71316
*cite journal | author=Bessho T, Sancar A |title=Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7451–4 |year= 2000 |pmid= 10713044 |doi=
*cite journal | author=Hang H, Lieberman HB |title=Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression. |journal=Genomics |volume=65 |issue= 1 |pages= 24–33 |year= 2000 |pmid= 10777662 |doi= 10.1006/geno.2000.6142
*cite journal | author=Cai RL, Yan-Neale Y, Cueto MA, "et al." |title=HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27909–16 |year= 2000 |pmid= 10846170 |doi= 10.1074/jbc.M000168200
*cite journal | author=Burtelow MA, Kaufmann SH, Karnitz LM |title=Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26343–8 |year= 2000 |pmid= 10852904 |doi= 10.1074/jbc.M001244200
*cite journal | author=Rauen M, Burtelow MA, Dufault VM, Karnitz LM |title=The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29767–71 |year= 2000 |pmid= 10884395 |doi= 10.1074/jbc.M005782200
*cite journal | author=Komatsu K, Wharton W, Hang H, "et al." |title=PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition. |journal=Oncogene |volume=19 |issue= 46 |pages= 5291–7 |year= 2000 |pmid= 11077446 |doi= 10.1038/sj.onc.1203901
*cite journal | author=Chen MJ, Lin YT, Lieberman HB, "et al." |title=ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16580–6 |year= 2001 |pmid= 11278446 |doi= 10.1074/jbc.M008871200
*cite journal | author=Burtelow MA, Roos-Mattjus PM, Rauen M, "et al." |title=Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25903–9 |year= 2001 |pmid= 11340080 |doi= 10.1074/jbc.M102946200
*cite journal | author=Mäkiniemi M, Hillukkala T, Tuusa J, "et al." |title=BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 30399–406 |year= 2001 |pmid= 11395493 |doi= 10.1074/jbc.M102245200
*cite journal | author=St Onge RP, Besley BD, Park M, "et al." |title=DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41898–905 |year= 2001 |pmid= 11551919 |doi= 10.1074/jbc.M105152200
*cite journal | author=Xiang SL, Kumano T, Iwasaki SI, "et al." |title=The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 4 |pages= 932–40 |year= 2001 |pmid= 11573955 |doi= 10.1006/bbrc.2001.5685
*cite journal | author=Zou L, Cortez D, Elledge SJ |title=Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 198–208 |year= 2002 |pmid= 11799063 |doi= 10.1101/gad.950302
*cite journal | author=Griffith JD, Lindsey-Boltz LA, Sancar A |title=Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15233–6 |year= 2002 |pmid= 11907025 |doi= 10.1074/jbc.C200129200
*cite journal | author=Hang H, Zhang Y, Dunbrack RL, "et al." |title=Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1. |journal=Genomics |volume=79 |issue= 4 |pages= 487–92 |year= 2002 |pmid= 11944979 |doi= 10.1006/geno.2002.6737
*cite journal | author=Yoshida K, Komatsu K, Wang HG, Kufe D |title=c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3292–300 |year= 2002 |pmid= 11971963 |doi=

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