RAD1 homolog

RAD1 homolog (S. pombe), also known as RAD1, is a human gene.cite web | title = Entrez Gene: RAD1 RAD1 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5810| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.cite web | title = Entrez Gene: RAD1 RAD1 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5810| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bardwell AJ, Bardwell L, Johnson DK, Friedberg EC |title=Yeast DNA recombination and repair proteins Rad1 and Rad10 constitute a complex in vivo mediated by localized hydrophobic domains. |journal=Mol. Microbiol. |volume=8 |issue= 6 |pages= 1177–88 |year= 1993 |pmid= 8361362 |doi=
*cite journal | author=Parker AE, Van de Weyer I, Laus MC, "et al." |title=A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18332–9 |year= 1998 |pmid= 9660799 |doi=
*cite journal | author=Udell CM, Lee SK, Davey S |title=HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene. |journal=Nucleic Acids Res. |volume=26 |issue= 17 |pages= 3971–6 |year= 1998 |pmid= 9705507 |doi=
*cite journal | author=Freire R, Murguía JR, Tarsounas M, "et al." |title=Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. |journal=Genes Dev. |volume=12 |issue= 16 |pages= 2560–73 |year= 1998 |pmid= 9716408 |doi=
*cite journal | author=Bluyssen HA, van Os RI, Naus NC, "et al." |title=A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. |journal=Genomics |volume=54 |issue= 2 |pages= 331–7 |year= 1999 |pmid= 9828137 |doi= 10.1006/geno.1998.5582
*cite journal | author=Marathi UK, Dahlen M, Sunnerhagen P, "et al." |title=RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene. |journal=Genomics |volume=54 |issue= 2 |pages= 344–7 |year= 1999 |pmid= 9828139 |doi= 10.1006/geno.1998.5589
*cite journal | author=Volkmer E, Karnitz LM |title=Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 567–70 |year= 1999 |pmid= 9872989 |doi=
*cite journal | author=Dean FB, Lian L, O'Donnell M |title=cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. |journal=Genomics |volume=54 |issue= 3 |pages= 424–36 |year= 1999 |pmid= 9878245 |doi= 10.1006/geno.1998.5587
*cite journal | author=St Onge RP, Udell CM, Casselman R, Davey S |title=The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. |journal=Mol. Biol. Cell |volume=10 |issue= 6 |pages= 1985–95 |year= 1999 |pmid= 10359610 |doi=
*cite journal | author=Hang H, Lieberman HB |title=Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression. |journal=Genomics |volume=65 |issue= 1 |pages= 24–33 |year= 2000 |pmid= 10777662 |doi= 10.1006/geno.2000.6142
*cite journal | author=Cai RL, Yan-Neale Y, Cueto MA, "et al." |title=HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27909–16 |year= 2000 |pmid= 10846170 |doi= 10.1074/jbc.M000168200
*cite journal | author=Burtelow MA, Kaufmann SH, Karnitz LM |title=Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26343–8 |year= 2000 |pmid= 10852904 |doi= 10.1074/jbc.M001244200
*cite journal | author=Rauen M, Burtelow MA, Dufault VM, Karnitz LM |title=The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29767–71 |year= 2000 |pmid= 10884395 |doi= 10.1074/jbc.M005782200
*cite journal | author=Burtelow MA, Roos-Mattjus PM, Rauen M, "et al." |title=Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25903–9 |year= 2001 |pmid= 11340080 |doi= 10.1074/jbc.M102946200
*cite journal | author=Bao S, Tibbetts RS, Brumbaugh KM, "et al." |title=ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. |journal=Nature |volume=411 |issue= 6840 |pages= 969–74 |year= 2001 |pmid= 11418864 |doi= 10.1038/35082110
*cite journal | author=Xiang SL, Kumano T, Iwasaki SI, "et al." |title=The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 4 |pages= 932–40 |year= 2001 |pmid= 11573955 |doi= 10.1006/bbrc.2001.5685
*cite journal | author=Zou L, Cortez D, Elledge SJ |title=Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 198–208 |year= 2002 |pmid= 11799063 |doi= 10.1101/gad.950302
*cite journal | author=Griffith JD, Lindsey-Boltz LA, Sancar A |title=Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15233–6 |year= 2002 |pmid= 11907025 |doi= 10.1074/jbc.C200129200
*cite journal | author=Hang H, Zhang Y, Dunbrack RL, "et al." |title=Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1. |journal=Genomics |volume=79 |issue= 4 |pages= 487–92 |year= 2002 |pmid= 11944979 |doi= 10.1006/geno.2002.6737
*cite journal | author=Hirai I, Wang HG |title=A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25722–7 |year= 2002 |pmid= 11994305 |doi= 10.1074/jbc.M203079200

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes