NRD1

Nardilysin (N-arginine dibasic convertase)
Identifiers
Symbols	NRD1; hNRD1; hNRD2
External IDs	OMIM: 602651 MGI: 1201386 HomoloGene: 68260 GeneCards: NRD1 Gene
EC number	3.4.24.61
Gene Ontology Molecular function • metalloendopeptidase activity • protein binding • peptidase activity • zinc ion binding • metal ion binding • epidermal growth factor binding Cellular component • cytosol • cell surface Biological process • proteolysis • neuromuscular junction development • cell proliferation • cell migration • positive regulation of membrane protein ectodomain proteolysis • regulation of endopeptidase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4898	230598
Ensembl	ENSG00000078618	ENSMUSG00000053510
UniProt	O43847	Q8R1H1
RefSeq (mRNA)	NM_001101662.1	NM_146150.2
RefSeq (protein)	NP_001095132.1	NP_666262.2
Location (UCSC)	Chr 1: 52.25 – 52.34 Mb	Chr 4: 108.67 – 108.73 Mb
PubMed search	[1]	[2]

Nardilysin is a protein that in humans is encoded by the NRD1 gene.^[1][2][3]

Interactions

NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.^[4]

References

1. ^ Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P (May 1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J 327 ( Pt 3): 773–9. PMC 1218856. PMID 9581555. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218856. 
2. ^ Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R (Apr 1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics 47 (2): 238–45. doi:10.1006/geno.1997.5078. PMID 9479496. 
3. ^ "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4898. 
4. ^ Nishi, E; Prat A, Hospital V, Elenius K, Klagsbrun M (Jul. 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. (England) 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. ISSN 0261-4189. PMC 125525. PMID 11432822. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125525. 

Further reading

• Seidah NG, Prat A (2003). "Precursor convertases in the secretory pathway, cytosol and extracellular milieu.". Essays Biochem. 38: 79–94. PMID 12463163. 
• Hospital V, Prat A (2005). "Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation.". Protein Pept. Lett. 11 (5): 501–8. doi:10.2174/0929866043406508. PMID 15544571. 
• Winter AG, Pierotti AR (2001). "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines.". Biochem. J. 351 Pt 3: 755–64. PMC 1221416. PMID 11042131. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221416. 
• Nishi E, Prat A, Hospital V, et al. (2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration.". EMBO J. 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. PMC 125525. PMID 11432822. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125525. 
• Ma Z, Csuhai E, Chow KM, Hersh LB (2001). "Expression of the acidic stretch of nardilysin as a functional binding domain.". Biochemistry 40 (31): 9447–52. doi:10.1021/bi010538x. PMID 11478915. 
• Hospital V, Nishi E, Klagsbrun M, et al. (2003). "The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF).". Biochem. J. 367 (Pt 1): 229–38. doi:10.1042/BJ20020822. PMC 1222870. PMID 12095415. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222870. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Chow KM, Oakley O, Goodman J, et al. (2003). "Nardilysin cleaves peptides at monobasic sites.". Biochemistry 42 (7): 2239–44. doi:10.1021/bi027178d. PMID 12590613. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Nishi E, Hiraoka Y, Yoshida K, et al. (2006). "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme.". J. Biol. Chem. 281 (41): 31164–72. doi:10.1074/jbc.M601316200. PMID 16923819. 
• Bernstein HG, Stricker R, Dobrowolny H, et al. (2007). "Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons.". Neuroscience 146 (4): 1513–23. doi:10.1016/j.neuroscience.2007.02.057. PMID 17442499.