NBR1

Neighbor of BRCA1 gene 1
PDB rendering based on 1wj6.
Available structures PDB 1WJ6, 2BKF, 2CP8, 2G4S
Identifiers
Symbols	NBR1; 1A1-3B; FLJ55359; FLJ98272; KIAA0049; M17S2
External IDs	OMIM: 166945 MGI: 108498 HomoloGene: 7438 GeneCards: NBR1 Gene
Gene Ontology Molecular function • protein binding • zinc ion binding • ubiquitin binding • metal ion binding Cellular component • cytoplasm • lysosome • late endosome • autophagic vacuole • cytosol • sarcomere • cytoplasmic vesicle Biological process • macroautophagy • protein oligomerization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4077	17966
Ensembl	ENSG00000188554	ENSMUSG00000017119
UniProt	Q14596	Q05BC8
RefSeq (mRNA)	NM_005899.3	NM_008676.2
RefSeq (protein)	NP_005890.2	NP_032702.1
Location (UCSC)	Chr 17: 41.32 – 41.36 Mb	Chr 11: 101.41 – 101.44 Mb
PubMed search	[1]	[2]

Next to BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.^[1][2]

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.^[2]

Interactions

NBR1 has been shown to interact with FEZ1.^[3]

References

1. ^ Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304. 
2. ^ ^{a b} "Entrez Gene: NBR1 neighbor of BRCA1 gene 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4077. 
3. ^ Whitehouse, Caroline; Chambers Julie, Howe Kathy, Cobourne Martyn, Sharpe Paul, Solomon Ellen (Jan. 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. (Germany) 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312. 

Further reading

• Miki Y, Swensen J, Shattuck-Eidens D et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science 266 (5182): 66–71. doi:10.1126/science.7545954. PMID 7545954. 
• Harshman K, Bell R, Rosenthal J et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259–1266. doi:10.1093/hmg/4.8.1259. PMID 7581362. 
• Nomura N, Nagase T, Miyajima N et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–229. doi:10.1093/dnares/1.5.223. PMID 7584044. 
• Brown MA, Nicolai H, Xu CF et al. (1995). "Regulation of BRCA1". Nature 372 (6508): 733–733. doi:10.1038/372733a0. PMID 7997258. 
• Brown MA, Xu CF, Nicolai H et al. (1996). "The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21". Oncogene 12 (12): 2507–13. PMID 8700509. 
• Dimitrov S, Brennerova M, Forejt J (2001). "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes". Gene 262 (1–2): 89–98. doi:10.1016/S0378-1119(00)00549-7. PMID 11179671. 
• Whitehouse C, Chambers J, Howe K et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312. 
• Wistow G, Bernstein SL, Ray S et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Lamark T, Perander M, Outzen H et al. (2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins". J. Biol. Chem. 278 (36): 34568–34581. doi:10.1074/jbc.M303221200. PMID 12813044. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Lange S, Xiang F, Yakovenko A et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science 308 (5728): 1599–1603. doi:10.1126/science.1110463. PMID 15802564. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Lincoln Mall MBNL1 Look at other dictionaries: CIB1 — Calcium and integrin binding 1 (calmyrin), also known as CIB1, is a human gene.cite web | title = Entrez Gene: CIB1 calcium and integrin binding 1 (calmyrin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia FEZ1 — Fasciculation and elongation protein zeta 1 (zygin I), also known as FEZ1, is a human gene.cite web | title = Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”