FEZ1

Fasciculation and elongation protein zeta 1 (zygin I), also known as FEZ1, is a human gene.cite web | title = Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9638| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.cite web | title = Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9638| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bloom L, Horvitz HR |title=The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 3414–9 |year= 1997 |pmid= 9096408 |doi=
*cite journal | author=Kuroda S, Nakagawa N, Tokunaga C, "et al." |title=Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. |journal=J. Cell Biol. |volume=144 |issue= 3 |pages= 403–11 |year= 1999 |pmid= 9971736 |doi=
*cite journal | author=Whitehouse C, Chambers J, Howe K, "et al." |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube. |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 538–45 |year= 2002 |pmid= 11856312 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Miyoshi K, Honda A, Baba K, "et al." |title=Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. |journal=Mol. Psychiatry |volume=8 |issue= 7 |pages= 685–94 |year= 2004 |pmid= 12874605 |doi= 10.1038/sj.mp.4001352
*cite journal | author=Surpili MJ, Delben TM, Kobarg J |title=Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. |journal=Biochemistry |volume=42 |issue= 51 |pages= 15369–76 |year= 2004 |pmid= 14690447 |doi= 10.1021/bi034575v
*cite journal | author=Goehler H, Lalowski M, Stelzl U, "et al." |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016
*cite journal | author=Okumura F, Hatakeyama S, Matsumoto M, "et al." |title=Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53533–43 |year= 2005 |pmid= 15466860 |doi= 10.1074/jbc.M402916200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Yamada K, Nakamura K, Minabe Y, "et al." |title=Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts. |journal=Biol. Psychiatry |volume=56 |issue= 9 |pages= 683–90 |year= 2005 |pmid= 15522253 |doi= 10.1016/j.biopsych.2004.08.015
*cite journal | author=Suzuki T, Okada Y, Semba S, "et al." |title=Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 24948–56 |year= 2005 |pmid= 15843383 |doi= 10.1074/jbc.M411499200
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Assmann EM, Alborghetti MR, Camargo ME, Kobarg J |title=FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 9869–81 |year= 2006 |pmid= 16484223 |doi= 10.1074/jbc.M513280200
*cite journal | author=Blasius TL, Cai D, Jih GT, "et al." |title=Two binding partners cooperate to activate the molecular motor Kinesin-1. |journal=J. Cell Biol. |volume=176 |issue= 1 |pages= 11–7 |year= 2007 |pmid= 17200414 |doi= 10.1083/jcb.200605099
*cite journal | author=Koga M, Ishiguro H, Horiuchi Y, "et al." |title=Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population. |journal=Neurosci. Lett. |volume=417 |issue= 3 |pages= 326–9 |year= 2007 |pmid= 17374448 |doi= 10.1016/j.neulet.2007.02.055

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