PDLIM1

PDZ and LIM domain 1
PDB rendering based on 1x62.
Available structures PDB 1X62, 2PKT
Identifiers
Symbols	PDLIM1; CLIM1; CLP-36; CLP36; hCLIM1
External IDs	OMIM: 605900 MGI: 1860611 HomoloGene: 9643 GeneCards: PDLIM1 Gene
Gene Ontology Molecular function • zinc ion binding • metal ion binding Cellular component • cytoplasm • cytoskeleton Biological process • response to hypoxia • response to oxidative stress Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9124	54132
Ensembl	ENSG00000107438	ENSMUSG00000055044
UniProt	O00151	Q3TZ17
RefSeq (mRNA)	NM_020992	NM_016861.4
RefSeq (protein)	NP_066272	NP_058557.2
Location (UCSC)	Chr 10: 97 – 97.05 Mb	Chr 19: 40.3 – 40.35 Mb
PubMed search	[1]	[2]

PDZ and LIM domain protein 1 is a protein that in humans is encoded by the PDLIM1 gene.^[1][2]

Interactions

PDLIM1 has been shown to interact with Estrogen receptor alpha,^[3] Actinin alpha 4,^[4][5] Actinin, alpha 1^[5][6] and RNF12.^[3]

References

1. ^ Kotaka M, Kostin S, Ngai S, Chan K, Lau Y, Lee SM, Li H, Ng EK, Schaper J, Tsui SK, Fung K, Lee C, Waye MM (Oct 2000). "Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2". J Cell Biochem 78 (4): 558–65. doi:10.1002/1097-4644(20000915)78:4<558::AID-JCB5>3.0.CO;2-I. PMID 10861853. 
2. ^ "Entrez Gene: PDLIM1 PDZ and LIM domain 1 (elfin)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9124. 
3. ^ ^{a b} Johnsen, Steven A; Güngör Cenap, Prenzel Tanja, Riethdorf Sabine, Riethdorf Lutz, Taniguchi-Ishigaki Naoko, Rau Thomas, Tursun Baris, Furlow J David, Sauter Guido, Scheffner Martin, Pantel Klaus, Gannon Frank, Bach Ingolf (Jan. 2009). "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer". Cancer Res. (United States) 69 (1): 128–36. doi:10.1158/0008-5472.CAN-08-1630. PMC 2713826. PMID 19117995. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2713826. 
4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
5. ^ ^{a b} Vallenius, T; Luukko K, Mäkelä T P (Apr. 2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4". J. Biol. Chem. (UNITED STATES) 275 (15): 11100–5. doi:10.1074/jbc.275.15.11100. ISSN 0021-9258. PMID 10753915. 
6. ^ Bauer, K; Kratzer M, Otte M, de Quintana K L, Hagmann J, Arnold G J, Eckerskorn C, Lottspeich F, Siess W (Dec. 2000). "Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells". Blood (UNITED STATES) 96 (13): 4236–45. ISSN 0006-4971. PMID 11110697. 

Further reading

• Wang H, Harrison-Shostak DC, Lemasters JJ, Herman B (1996). "Cloning of a rat cDNA encoding a novel LIM domain protein with high homology to rat RIL.". Gene 165 (2): 267–71. doi:10.1016/0378-1119(95)00542-E. PMID 8522188. 
• Kotaka M, Ngai SM, Garcia-Barcelo M, et al. (1999). "Characterization of the human 36-kDa carboxyl terminal LIM domain protein (hCLIM1).". J. Cell. Biochem. 72 (2): 279–85. doi:10.1002/(SICI)1097-4644(19990201)72:2<279::AID-JCB12>3.0.CO;2-7. PMID 10022510. 
• Vallenius T, Luukko K, Mäkelä TP (2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4.". J. Biol. Chem. 275 (15): 11100–5. doi:10.1074/jbc.275.15.11100. PMID 10753915. 
• Bauer K, Kratzer M, Otte M, et al. (2001). "Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells.". Blood 96 (13): 4236–45. PMID 11110697. 
• Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.". Nature 416 (6876): 99–103. doi:10.1038/416099a. PMID 11882901. 
• Vallenius T, Mäkelä TP (2003). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein.". J. Cell. Sci. 115 (Pt 10): 2067–73. PMID 11973348. 
• Kioussi C, Briata P, Baek SH, et al. (2003). "Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development.". Cell 111 (5): 673–85. doi:10.1016/S0092-8674(02)01084-X. PMID 12464179. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186. 
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Miehe U, Kadyrov M, Neumaier-Wagner P, et al. (2007). "Expression of the actin stress fiber-associated protein CLP36 in the human placenta.". Histochem. Cell Biol. 126 (4): 465–71. doi:10.1007/s00418-006-0182-5. PMID 16609848.