- RNF12
Ring finger protein 12, also known as RNF12, is a human
gene .cite web | title = Entrez Gene: RNF12 ring finger protein 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51132| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.cite web | title = Entrez Gene: RNF12 ring finger protein 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51132| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hiratani I, Yamamoto N, Mochizuki T, "et al." |title=Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions. |journal=Development |volume=130 |issue= 17 |pages= 4161-75 |year= 2003 |pmid= 12874135 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ostendorff HP, Peirano RI, Peters MA, "et al." |title=Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. |journal=Nature |volume=416 |issue= 6876 |pages= 99-103 |year= 2002 |pmid= 11882901 |doi= 10.1038/416099a
*cite journal | author=Ostendorff HP, Bossenz M, Mincheva A, "et al." |title=Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors. |journal=Genomics |volume=69 |issue= 1 |pages= 120-30 |year= 2001 |pmid= 11013082 |doi= 10.1006/geno.2000.6311
*cite journal | author=Scanlan MJ, Gordan JD, Williamson B, "et al." |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi=
*cite journal | author=Bach I, Rodriguez-Esteban C, Carrière C, "et al." |title=RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 394-9 |year= 1999 |pmid= 10431247 |doi= 10.1038/11970PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
Wikimedia Foundation. 2010.
