DGCR8 (gene)

DiGeorge syndrome critical region gene 8
PDB rendering based on 1x47.
Available structures PDB 1X47, 2YT4, 3LE4
Identifiers
Symbols	DGCR8; C22orf12; DGCRK6; Gy1; pasha
External IDs	OMIM: 609030 MGI: 2151114 HomoloGene: 11223 GeneCards: DGCR8 Gene
Gene Ontology Molecular function • double-stranded RNA binding • protein binding • metal ion binding Cellular component • intracellular • nucleus • nucleoplasm • nucleolus • cytoplasm • microtubule cytoskeleton Biological process • primary microRNA processing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54487	94223
Ensembl	ENSG00000128191	ENSMUSG00000022718
UniProt	Q8WYQ5	Q9EQM6
RefSeq (mRNA)	NM_001190326.1	NM_033324.2
RefSeq (protein)	NP_001177255.1	NP_201581.2
Location (UCSC)	Chr 22: 20.07 – 20.1 Mb	Chr 16: 18.25 – 18.29 Mb
PubMed search	[1]	[2]

Microprocessor complex subunit DGCR8 is a protein that in humans is encoded by the DGCR8 gene.^[1]

References

1. ^ "Entrez Gene: DGCR8 DiGeorge syndrome critical region gene 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54487. 

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Shiohama A, Sasaki T, Noda S, et al. (2003). "Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region.". Biochem. Biophys. Res. Commun. 304 (1): 184–90. doi:10.1016/S0006-291X(03)00554-0. PMID 12705904. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545604. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930. 
• Gregory RI, Yan KP, Amuthan G, et al. (2004). "The Microprocessor complex mediates the genesis of microRNAs.". Nature 432 (7014): 235–40. doi:10.1038/nature03120. PMID 15531877. 
• Han J, Lee Y, Yeom KH, et al. (2005). "The Drosha-DGCR8 complex in primary microRNA processing.". Genes Dev. 18 (24): 3016–27. doi:10.1101/gad.1262504. PMC 535913. PMID 15574589. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=535913. 
• Landthaler M, Yalcin A, Tuschl T (2005). "The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.". Curr. Biol. 14 (23): 2162–7. doi:10.1016/j.cub.2004.11.001. PMID 15589161. 
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501. 
• Han J, Lee Y, Yeom KH, et al. (2006). "Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.". Cell 125 (5): 887–901. doi:10.1016/j.cell.2006.03.043. PMID 16751099. 
• Faller M, Matsunaga M, Yin S, et al. (2007). "Heme is involved in microRNA processing.". Nat. Struct. Mol. Biol. 14 (1): 23–9. doi:10.1038/nsmb1182. PMID 17159994. 
• Sohn SY, Bae WJ, Kim JJ, et al. (2007). "Crystal structure of human DGCR8 core.". Nat. Struct. Mol. Biol. 14 (9): 847–53. doi:10.1038/nsmb1294. PMID 17704815.