NUB1

Negative regulator of ubiquitin-like proteins 1
PDB rendering based on 1wju.
Available structures PDB 1wju
Identifiers
Symbols	NUB1; BS4; NUB1L; NYREN18
External IDs	OMIM: 607981 MGI: 1889001 HomoloGene: 41108 GeneCards: NUB1 Gene
Gene Ontology Molecular function • protein binding Cellular component • nucleus Biological process • ubiquitin-dependent protein catabolic process • protein ubiquitination • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • response to interferon-gamma • response to tumor necrosis factor Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51667	53312
Ensembl	ENSG00000013374	ENSMUSG00000028954
UniProt	Q9Y5A7	A0JLP6
RefSeq (mRNA)	NM_016118	NM_016736.2
RefSeq (protein)	NP_057202	NP_058016.2
Location (UCSC)	Chr 7: 151.04 – 151.08 Mb	Chr 5: 24.19 – 24.22 Mb
PubMed search	[1]	[2]

NEDD8 ultimate buster 1 is a protein that in humans is encoded by the NUB1 gene.^[1][2][3]

NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a ubiquitin-like protein that covalently conjugates to cullin (see MIM 603134) family members.[supplied by OMIM]^[3]

Interactions

NUB1 has been shown to interact with NEDD8,^[4][5] UBD^[4] and AIPL1.^[6]

References

1. ^ Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jager D, Jager E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int J Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. 
2. ^ Kito K, Yeh ET, Kamitani T (Jun 2001). "NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression". J Biol Chem 276 (23): 20603–9. doi:10.1074/jbc.M100920200. PMID 11259415. 
3. ^ ^{a b} "Entrez Gene: NUB1 negative regulator of ubiquitin-like proteins 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51667. 
4. ^ ^{a b} Hipp, Mark Steffen; Raasi Shahri, Groettrup Marcus, Schmidtke Gunter (Apr. 2004). "NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation". J. Biol. Chem. (United States) 279 (16): 16503–10. doi:10.1074/jbc.M310114200. ISSN 0021-9258. PMID 14757770. 
5. ^ Kamitani, T; Kito K, Fukuda-Kamitani T, Yeh E T (Dec. 2001). "Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1". J. Biol. Chem. (United States) 276 (49): 46655–60. doi:10.1074/jbc.M108636200. ISSN 0021-9258. PMID 11585840. 
6. ^ Akey, Dayna T; Zhu Xuemei, Dyer Michael, Li Aimin, Sorensen Adam, Blackshaw Seth, Fukuda-Kamitani Taeko, Daiger Stephen P, Craft Cheryl M, Kamitani Tetsu, Sohocki Melanie M (Oct. 2002). "The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1". Hum. Mol. Genet. (England) 11 (22): 2723–33. doi:10.1093/hmg/11.22.2723. ISSN 0964-6906. PMC 2585502. PMID 12374762. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2585502. 

Further reading

• Kamitani T, Kito K, Fukuda-Kamitani T, Yeh ET (2002). "Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1.". J. Biol. Chem. 276 (49): 46655–60. doi:10.1074/jbc.M108636200. PMID 11585840. 
• Akey DT, Zhu X, Dyer M, et al. (2003). "The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1.". Hum. Mol. Genet. 11 (22): 2723–33. doi:10.1093/hmg/11.22.2723. PMC 2585502. PMID 12374762. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2585502. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Tanaka T, Kawashima H, Yeh ET, Kamitani T (2003). "Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L.". J. Biol. Chem. 278 (35): 32905–13. doi:10.1074/jbc.M212057200. PMID 12816948. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622. 
• van der Spuy J, Kim JH, Yu YS, et al. (2003). "The expression of the Leber congenital amaurosis protein AIPL1 coincides with rod and cone photoreceptor development.". Invest. Ophthalmol. Vis. Sci. 44 (12): 5396–403. doi:10.1167/iovs.03-0686. PMID 14638743. 
• Hipp MS, Raasi S, Groettrup M, Schmidtke G (2004). "NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation.". J. Biol. Chem. 279 (16): 16503–10. doi:10.1074/jbc.M310114200. PMID 14757770. 
• Tanaka T, Yeh ET, Kamitani T (2004). "NUB1-mediated targeting of the ubiquitin precursor UbC1 for its C-terminal hydrolysis.". Eur. J. Biochem. 271 (5): 972–82. doi:10.1111/j.1432-1033.2004.03999.x. PMID 15009209. 
• Kanaya K, Sohocki MM, Kamitani T (2004). "Abolished interaction of NUB1 with mutant AIPL1 involved in Leber congenital amaurosis.". Biochem. Biophys. Res. Commun. 317 (3): 768–73. doi:10.1016/j.bbrc.2004.03.108. PMID 15081406. 
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• van der Spuy J, Cheetham ME (2005). "The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments.". J. Biol. Chem. 279 (46): 48038–47. doi:10.1074/jbc.M407871200. PMID 15347646. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Schmidtke G, Kalveram B, Weber E, et al. (2006). "The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10.". J. Biol. Chem. 281 (29): 20045–54. doi:10.1074/jbc.M603063200. PMID 16707496. 
• Tanji K, Tanaka T, Mori F, et al. (2006). "NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1.". Am. J. Pathol. 169 (2): 553–65. doi:10.2353/ajpath.2006.051067. PMC 1698792. PMID 16877356. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1698792.