Phosphatidic acid phosphatase 2c

Phosphatidic acid phosphatase 2c

Phosphatidic acid phosphatase type 2C, also known as PPAP2C, is a human gene.cite web | title = Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Nanjundan M, Possmayer F |title=Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=284 |issue= 1 |pages= L1–23 |year= 2003 |pmid= 12471011 |doi= 10.1152/ajplung.00029.2002
*cite journal | author=Morris KE, Schang LM, Brindley DN |title=Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts. |journal=J. Biol. Chem. |volume=281 |issue= 14 |pages= 9297–306 |year= 2006 |pmid= 16467304 |doi= 10.1074/jbc.M511710200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang N, Sundberg JP, Gridley T |title=Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile. |journal=Genesis |volume=27 |issue= 4 |pages= 137–40 |year= 2000 |pmid= 10992322 |doi=
*cite journal | author=Roberts R, Sciorra VA, Morris AJ |title=Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 22059–67 |year= 1998 |pmid= 9705349 |doi=
*cite journal | author=Hooks SB, Ragan SP, Lynch KR |title=Identification of a novel human phosphatidic acid phosphatase type 2 isoform. |journal=FEBS Lett. |volume=427 |issue= 2 |pages= 188–92 |year= 1998 |pmid= 9607309 |doi=
*cite journal | author=Leung DW, Tompkins CK, White T |title=Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells. |journal=DNA Cell Biol. |volume=17 |issue= 4 |pages= 377–85 |year= 1998 |pmid= 9570154 |doi=

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