LPIN1

Lipin 1, also known as LPIN1, is a human gene.cite web | title = Entrez Gene: LPIN1 lipin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23175| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism.cite web | title = Entrez Gene: LPIN1 lipin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23175| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Seki N, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=3 |issue= 1 |pages= 17–24 |year= 1996 |pmid= 8724849 |doi=
*cite journal | author=Péterfy M, Phan J, Oswell GM, "et al." |title=Genetic, physical, and transcript map of the fld region on mouse chromosome 12. |journal=Genomics |volume=62 |issue= 3 |pages= 436–44 |year= 2000 |pmid= 10644441 |doi= 10.1006/geno.1999.6023
*cite journal | author=Reue K, Xu P, Wang XP, Slavin BG |title=Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene. |journal=J. Lipid Res. |volume=41 |issue= 7 |pages= 1067–76 |year= 2000 |pmid= 10884287 |doi=
*cite journal | author=Péterfy M, Phan J, Xu P, Reue K |title=Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. |journal=Nat. Genet. |volume=27 |issue= 1 |pages= 121–4 |year= 2001 |pmid= 11138012 |doi= 10.1038/83685
*cite journal | author=Huffman TA, Mothe-Satney I, Lawrence JC |title=Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 1047–52 |year= 2002 |pmid= 11792863 |doi= 10.1073/pnas.022634399
*cite journal | author=Cao H, Hegele RA |title=Identification of single-nucleotide polymorphisms in the human LPIN1 gene. |journal=J. Hum. Genet. |volume=47 |issue= 7 |pages= 370–2 |year= 2003 |pmid= 12111372 |doi= 10.1007/s100380200052
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Suviolahti E, Reue K, Cantor RM, "et al." |title=Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism. |journal=Hum. Mol. Genet. |volume=15 |issue= 3 |pages= 377–86 |year= 2006 |pmid= 16357106 |doi= 10.1093/hmg/ddi448
*cite journal | author=Han GS, Wu WI, Carman GM |title=The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme. |journal=J. Biol. Chem. |volume=281 |issue= 14 |pages= 9210–8 |year= 2006 |pmid= 16467296 |doi= 10.1074/jbc.M600425200
*cite journal | author=Finck BN, Gropler MC, Chen Z, "et al." |title=Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. |journal=Cell Metab. |volume=4 |issue= 3 |pages= 199–210 |year= 2006 |pmid= 16950137 |doi= 10.1016/j.cmet.2006.08.005
*cite journal | author=Yao-Borengasser A, Rasouli N, Varma V, "et al." |title=Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. |journal=Diabetes |volume=55 |issue= 10 |pages= 2811–8 |year= 2006 |pmid= 17003347 |doi= 10.2337/db05-1688
*cite journal | author=van Harmelen V, Rydén M, Sjölin E, Hoffstedt J |title=A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression. |journal=J. Lipid Res. |volume=48 |issue= 1 |pages= 201–6 |year= 2007 |pmid= 17035674 |doi= 10.1194/jlr.M600272-JLR200
*cite journal | author=Harris TE, Huffman TA, Chi A, "et al." |title=Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. |journal=J. Biol. Chem. |volume=282 |issue= 1 |pages= 277–86 |year= 2007 |pmid= 17105729 |doi= 10.1074/jbc.M609537200
*cite journal | author=Croce MA, Eagon JC, LaRiviere LL, "et al." |title=Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss. |journal=Diabetes |volume=56 |issue= 9 |pages= 2395–9 |year= 2007 |pmid= 17563064 |doi= 10.2337/db07-0480

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