PPAP2A

Phosphatidic acid phosphatase type 2A, also known as PPAP2A, is a human gene.cite web | title = Entrez Gene: PPAP2A phosphatidic acid phosphatase type 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8611| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described.cite web | title = Entrez Gene: PPAP2A phosphatidic acid phosphatase type 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8611| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kanoh H, Kai M, Wada I |title=Molecular characterization of the type 2 phosphatidic acid phosphatase. |journal=Chem. Phys. Lipids |volume=98 |issue= 1-2 |pages= 119–26 |year= 1999 |pmid= 10358934 |doi=
*cite journal | author=Nanjundan M, Possmayer F |title=Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=284 |issue= 1 |pages= L1–23 |year= 2003 |pmid= 12471011 |doi= 10.1152/ajplung.00029.2002
*cite journal | author=Kai M, Wada I, Imai S, "et al." |title=Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24572–8 |year= 1997 |pmid= 9305923 |doi=
*cite journal | author=Ulrix W, Swinnen JV, Heyns W, Verhoeven G |title=Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic adenocarcinoma cell line LNCaP. |journal=J. Biol. Chem. |volume=273 |issue= 8 |pages= 4660–5 |year= 1998 |pmid= 9468526 |doi=
*cite journal | author=Leung DW, Tompkins CK, White T |title=Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells. |journal=DNA Cell Biol. |volume=17 |issue= 4 |pages= 377–85 |year= 1998 |pmid= 9570154 |doi=
*cite journal | author=Hooks SB, Ragan SP, Lynch KR |title=Identification of a novel human phosphatidic acid phosphatase type 2 isoform. |journal=FEBS Lett. |volume=427 |issue= 2 |pages= 188–92 |year= 1998 |pmid= 9607309 |doi=
*cite journal | author=Roberts R, Sciorra VA, Morris AJ |title=Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 22059–67 |year= 1998 |pmid= 9705349 |doi=
*cite journal | author=Neumann J, Maas R, Bokník P, "et al." |title=Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts. |journal=J. Pharmacol. Exp. Ther. |volume=289 |issue= 1 |pages= 188–93 |year= 1999 |pmid= 10087003 |doi=
*cite journal | author=Moreno CS, Park S, Nelson K, "et al." |title=WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5257–63 |year= 2000 |pmid= 10681496 |doi=
*cite journal | author=Roberts RZ, Morris AJ |title=Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators. |journal=Biochim. Biophys. Acta |volume=1487 |issue= 1 |pages= 33–49 |year= 2001 |pmid= 10962286 |doi=
*cite journal | author=Woetmann A, Brockdorff J, Lovato P, "et al." |title=Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 2787–91 |year= 2003 |pmid= 12426308 |doi= 10.1074/jbc.M210196200
*cite journal | author=Pandey AV, Mellon SH, Miller WL |title=Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 2837–44 |year= 2003 |pmid= 12444089 |doi= 10.1074/jbc.M209527200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Smyth SS, Sciorra VA, Sigal YJ, "et al." |title=Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43214–23 |year= 2003 |pmid= 12909631 |doi= 10.1074/jbc.M306709200
*cite journal | author=Tanyi JL, Hasegawa Y, Lapushin R, "et al." |title=Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer. |journal=Clin. Cancer Res. |volume=9 |issue= 10 Pt 1 |pages= 3534–45 |year= 2004 |pmid= 14506139 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Grkovich A, Johnson CA, Buczynski MW, Dennis EA |title=Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent. |journal=J. Biol. Chem. |volume=281 |issue= 44 |pages= 32978–87 |year= 2006 |pmid= 16950767 |doi= 10.1074/jbc.M605935200
*cite journal | author=Kai M, Sakane F, Jia YJ, "et al." |title=Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts. |journal=J. Biochem. |volume=140 |issue= 5 |pages= 677–86 |year= 2007 |pmid= 17005594 |doi= 10.1093/jb/mvj195

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