NEK6

NEK6
NIMA (never in mitosis gene a)-related kinase 6
Identifiers
Symbols NEK6; SID6-1512
External IDs OMIM604884 MGI1891638 HomoloGene49379 GeneCards: NEK6 Gene
EC number 2.7.11.1
Orthologs
Species Human Mouse
Entrez 10783 59126
Ensembl ENSG00000119408 ENSMUSG00000026749
UniProt Q9HC98 n/a
RefSeq (mRNA) NM_001145001.2 NM_021606
RefSeq (protein) NP_001138473.1 NP_067619
Location (UCSC) Chr 9:
127.02 – 127.12 Mb
Chr 2:
38.37 – 38.44 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.[1][2]

The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[supplied by OMIM][2]

Interactions

NEK6 has been shown to interact with NEK9.[3][4][5]

References

  1. ^ Li MZ, Yu L, Liu Q, Chu JY, Zhao SY (April 2000). "Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3→q34.11 by radiation hybrid mapping". Cytogenet Cell Genet 87 (3–4): 271–2. doi:10.1159/000015445. PMID 10702691. 
  2. ^ a b "Entrez Gene: NEK6 NIMA (never in mitosis gene a)-related kinase 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10783. 
  3. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
  4. ^ Belham, Christopher; Roig Joan, Caldwell Jennifer A, Aoyama Yumi, Kemp Bruce E, Comb Michael, Avruch Joseph (September 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". J. Biol. Chem. (United States) 278 (37): 34897–909. doi:10.1074/jbc.M303663200. ISSN 0021-9258. PMID 12840024. 
  5. ^ Roig, Joan; Mikhailov Alexei, Belham Christopher, Avruch Joseph (July 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes Dev. (United States) 16 (13): 1640–58. doi:10.1101/gad.972202. ISSN 0890-9369. PMC 186374. PMID 12101123. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=186374. 

Further reading



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Look at other dictionaries:

  • NEK9 — NIMA (never in mitosis gene a) related kinase 9 Identifiers Symbols NEK9; DKFZp434D0935; MGC138306; MGC16714; NERCC; NERCC1; Nek8 External IDs …   Wikipedia

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  • Protein kinase domain — Pfam box Symbol = Pkinase Name = Protein kinase domain width = caption = Pfam= PF00069 InterPro= IPR000719 SMART= TyrKc PROSITE = PDOC00629 SCOP = 1apm TCDB = OPM family= OPM protein= 2bcj PDB=PDB3|1ctpE:44 298 PDB3|2erzE:44 298 PDB3|1fotA:87 341 …   Wikipedia

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