OGN (gene)

OGN (gene)
Osteoglycin
Identifiers
Symbols OGN; DKFZp586P2421; OG; OIF; SLRR3A
External IDs OMIM602383 MGI109278 HomoloGene8542 GeneCards: OGN Gene
RNA expression pattern
PBB GE OGN 218730 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4969 18295
Ensembl ENSG00000106809 ENSMUSG00000021390
UniProt P20774 Q543C5
RefSeq (mRNA) NM_014057.3 NM_008760.4
RefSeq (protein) NP_054776.1 NP_032786.1
Location (UCSC) Chr 9:
95.15 – 95.17 Mb
Chr 13:
49.7 – 49.72 Mb
PubMed search [1] [2]

Osteoglycin(also Mimecan), encoded by the OGN gene is a human protein.[1]

This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.[1]

The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.[2][3]

References

  1. ^ a b "Entrez Gene: OGN osteoglycin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4969. 
  2. ^ "Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. http://news.bbc.co.uk/2/hi/health/7371213.stm. Retrieved 2008-06-07. 
  3. ^ Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC 2742198. PMID 18443592. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2742198. 

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