- GADD45A
Growth arrest and DNA-damage-inducible, alpha, also known as GADD45A, is a human
gene .cite web | title = Entrez Gene: GADD45A growth arrest and DNA-damage-inducible, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1647| accessdate = ]PBB_Summary
section_title =
summary_text = This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.cite web | title = Entrez Gene: GADD45A growth arrest and DNA-damage-inducible, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1647| accessdate = ]ee also
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Gadd45 References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Hildesheim J, Fornace AJ |title=Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer. |journal=Clin. Cancer Res. |volume=8 |issue= 8 |pages= 2475–9 |year= 2003 |pmid= 12171872 |doi=
*cite journal | author=Papathanasiou MA, Kerr NC, Robbins JH, "et al." |title=Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. |journal=Mol. Cell. Biol. |volume=11 |issue= 2 |pages= 1009–16 |year= 1991 |pmid= 1990262 |doi=
*cite journal | author=Chen IT, Smith ML, O'Connor PM, Fornace AJ |title=Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA. |journal=Oncogene |volume=11 |issue= 10 |pages= 1931–7 |year= 1995 |pmid= 7478510 |doi=
*cite journal | author=Kearsey JM, Coates PJ, Prescott AR, "et al." |title=Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1. |journal=Oncogene |volume=11 |issue= 9 |pages= 1675–83 |year= 1995 |pmid= 7478594 |doi=
*cite journal | author=Hall PA, Kearsey JM, Coates PJ, "et al." |title=Characterisation of the interaction between PCNA and Gadd45. |journal=Oncogene |volume=10 |issue= 12 |pages= 2427–33 |year= 1995 |pmid= 7784094 |doi=
*cite journal | author=Carrier F, Smith ML, Bae I, "et al." |title=Characterization of human Gadd45, a p53-regulated protein. |journal=J. Biol. Chem. |volume=269 |issue= 51 |pages= 32672–7 |year= 1995 |pmid= 7798274 |doi=
*cite journal | author=Smith ML, Chen IT, Zhan Q, "et al." |title=Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. |journal=Science |volume=266 |issue= 5189 |pages= 1376–80 |year= 1994 |pmid= 7973727 |doi=
*cite journal | author=Hollander MC, Alamo I, Jackman J, "et al." |title=Analysis of the mammalian gadd45 gene and its response to DNA damage. |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 24385–93 |year= 1993 |pmid= 8226988 |doi=
*cite journal | author=Warbrick E, Lane DP, Glover DM, Cox LS |title=Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair. |journal=Oncogene |volume=14 |issue= 19 |pages= 2313–21 |year= 1997 |pmid= 9178907 |doi= 10.1038/sj.onc.1201072
*cite journal | author=Warbrick E, Heatherington W, Lane DP, Glover DM |title=PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain. |journal=Nucleic Acids Res. |volume=26 |issue= 17 |pages= 3925–32 |year= 1998 |pmid= 9705499 |doi=
*cite journal | author=Takekawa M, Saito H |title=A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. |journal=Cell |volume=95 |issue= 4 |pages= 521–30 |year= 1998 |pmid= 9827804 |doi=
*cite journal | author=Carrier F, Georgel PT, Pourquier P, "et al." |title=Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1673–85 |year= 1999 |pmid= 10022855 |doi=
*cite journal | author=Zhan Q, Antinore MJ, Wang XW, "et al." |title=Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. |journal=Oncogene |volume=18 |issue= 18 |pages= 2892–900 |year= 1999 |pmid= 10362260 |doi= 10.1038/sj.onc.1202667
*cite journal | author=Jin S, Antinore MJ, Lung FD, "et al." |title=The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16602–8 |year= 2000 |pmid= 10747892 |doi= 10.1074/jbc.M000284200
*cite journal | author=Vairapandi M, Azam N, Balliet AG, "et al." |title=Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16810–9 |year= 2000 |pmid= 10828065 |doi=
*cite journal | author=Yi YW, Kim D, Jung N, "et al." |title=Gadd45 family proteins are coactivators of nuclear hormone receptors. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 1 |pages= 193–8 |year= 2000 |pmid= 10872826 |doi=
*cite journal | author=Zhao H, Jin S, Antinore MJ, "et al." |title=The central region of Gadd45 is required for its interaction with p21/WAF1. |journal=Exp. Cell Res. |volume=258 |issue= 1 |pages= 92–100 |year= 2000 |pmid= 10912791 |doi= 10.1006/excr.2000.4906
*cite journal | author=Yang Q, Manicone A, Coursen JD, "et al." |title=Identification of a functional domain in a GADD45-mediated G2/M checkpoint. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 36892–8 |year= 2001 |pmid= 10973963 |doi= 10.1074/jbc.M005319200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Kovalsky O, Lung FD, Roller PP, Fornace AJ |title=Oligomerization of human Gadd45a protein. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39330–9 |year= 2001 |pmid= 11498536 |doi= 10.1074/jbc.M105115200PBB_Controls
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