Gadd45

Gadd45

The Growth Arrest and DNA Damage or "gadd45" genes, including Gene|GADD45A (originally termed gadd45) Gene|GADD45B (originally termed MyD118), and Gene|GADD45G (originally termed CR6), are implicated as stress sensors that modulate the response of mammalian cells to genotoxic/physiological stress, and modulate tumor formation. Gadd45 proteins interact with other proteins implicated in stress responses, including PCNA, p21, Cdc2/CyclinB1, MEKK4, and p38 kinase.cite journal|author=Fornace, A.J.; Jackman, J.; Hollander, M.C.; Hoffman-Liebermann, B.; & Liebermann, D.A.|title=Genotoxic-stress-response genes and growth-arrest genes: gadd, MyD, and other genes induced by treatments eliciting growth arrest|journal=Annals of the New York Academy of Sciences|volume=663|pages=139–153|year=1992|pmid=1482047] cite journal|author=Liebermann, D.A.|coauthors=Hoffman, B.|title=Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation|journal=Leukemia|volume=16|issue=4|pages=527–541|year=2002|pmid=11960329|doi=10.1038/sj.leu.2402477]

History

*Gadd45a was discovered & characterized in the laboratory of Dr. Albert Fornace Jr. in 1988.cite journal|author=Fornace, A.J.|coauthors=Alamo, I.; & Hollander, M.C.|title=DNA damage-inducible transcripts in mammalian cells|journal=Proceedings of the National Academy of Sciences|volume=85|issue=23|pages=8800–8804|year=1988|pmid=3194391]

*Gadd45b (MyD118) was discovered & characterized in the laboratories of Drs. Dan A. Liebermann and Barbara Hoffman in 1991.cite journal|author=Abdollahi, A.|coauthors=Lord, K.A.; Hoffman-Liebermann, B.; & Liebermann, D.A.|title=Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines|journal=Oncogene|volume=6|issue=1|pages=165–167|year=1991|pmid=1899477]

*Gadd45g (CR6) was discovered & characterized in the laboratories of Drs. Keneneth Smith, Dan A. Liebermann, and Barbara Hoffman in 1993 and 1999.cite journal|author=Zhang, W.; Bae, I.; Krishnaraju, K.; "et al"|title=CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control|journal=Oncogene|volume=18|issue=35|pages=4899–4907|year=1999|pmid=10490824|doi=10.1038/sj.onc.1202885] cite journal|author=Beadling, C.; Johnson, K.W.; & Smith, K.A.|title=Isolation of interleukin 2-induced immediate-early genes|journal=Proceedings of the National Academy of Sciences|volume=90|issue=7|pages=2719–2723|year=1993|pmid=7681987]

ee also

*GADD45A
*GADD45B
*GADD45G

References

External links

*


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  • GADD45A — Growth arrest and DNA damage inducible, alpha, also known as GADD45A, is a human gene.cite web | title = Entrez Gene: GADD45A growth arrest and DNA damage inducible, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView …   Wikipedia

  • GADD45B — Growth arrest and DNA damage inducible, beta, also known as GADD45B, is a human gene.cite web | title = Entrez Gene: GADD45B growth arrest and DNA damage inducible, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

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