GADD45B

Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a human gene.cite web | title = Entrez Gene: GADD45B growth arrest and DNA-damage-inducible, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4616| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.cite web | title = Entrez Gene: GADD45B growth arrest and DNA-damage-inducible, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4616| accessdate = ]

ee also

*Gadd45

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA |title=Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines. |journal=Oncogene |volume=6 |issue= 1 |pages= 165–7 |year= 1991 |pmid= 1899477 |doi=
*cite journal | author=Vairapandi M, Balliet AG, Fornace AJ, "et al." |title=The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. |journal=Oncogene |volume=12 |issue= 12 |pages= 2579–94 |year= 1996 |pmid= 8700517 |doi=
*cite journal | author=Koonin EV |title=Cell cycle and apoptosis: possible roles of Gadd45 and MyD118 proteins inferred from their homology to ribosomal proteins. |journal=J. Mol. Med. |volume=75 |issue= 4 |pages= 236–8 |year= 1997 |pmid= 9151207 |doi=
*cite journal | author=Takekawa M, Saito H |title=A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. |journal=Cell |volume=95 |issue= 4 |pages= 521–30 |year= 1998 |pmid= 9827804 |doi=
*cite journal | author=Sakaue M, Adachi H, Jetten AM |title=Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6- [3-(1-adamantyl)-4-hydroxyphenyl] -2- naphthalene carboxylic acid-induced apoptosis. |journal=Mol. Pharmacol. |volume=55 |issue= 4 |pages= 668–76 |year= 1999 |pmid= 10101024 |doi=
*cite journal | author=Gong R, Yu L, Zhang H, "et al." |title=Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1-2 |pages= 95–6 |year= 2000 |pmid= 10773677 |doi=
*cite journal | author=Vairapandi M, Azam N, Balliet AG, "et al." |title=Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16810–9 |year= 2000 |pmid= 10828065 |doi=
*cite journal | author=Yi YW, Kim D, Jung N, "et al." |title=Gadd45 family proteins are coactivators of nuclear hormone receptors. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 1 |pages= 193–8 |year= 2000 |pmid= 10872826 |doi=
*cite journal | author=Yang Q, Manicone A, Coursen JD, "et al." |title=Identification of a functional domain in a GADD45-mediated G2/M checkpoint. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 36892–8 |year= 2001 |pmid= 10973963 |doi= 10.1074/jbc.M005319200
*cite journal | author=Wan Y, Wang Z, Shao Y, "et al." |title=UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo. |journal=Int. J. Mol. Med. |volume=6 |issue= 6 |pages= 683–8 |year= 2001 |pmid= 11078829 |doi=
*cite journal | author=Kovalsky O, Lung FD, Roller PP, Fornace AJ |title=Oligomerization of human Gadd45a protein. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39330–9 |year= 2001 |pmid= 11498536 |doi= 10.1074/jbc.M105115200
*cite journal | author=Vairapandi M, Balliet AG, Hoffman B, Liebermann DA |title=GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. |journal=J. Cell. Physiol. |volume=192 |issue= 3 |pages= 327–38 |year= 2002 |pmid= 12124778 |doi= 10.1002/jcp.10140
*cite journal | author=Jin R, De Smaele E, Zazzeroni F, "et al." |title=Regulation of the gadd45beta promoter by NF-kappaB. |journal=DNA Cell Biol. |volume=21 |issue= 7 |pages= 491–503 |year= 2002 |pmid= 12162804 |doi= 10.1089/104454902320219059
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chung HK, Yi YW, Jung NC, "et al." |title=CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28079–88 |year= 2003 |pmid= 12716909 |doi= 10.1074/jbc.M212835200
*cite journal | author=Qiu W, David D, Zhou B, "et al." |title=Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. |journal=Am. J. Pathol. |volume=162 |issue= 6 |pages= 1961–74 |year= 2003 |pmid= 12759252 |doi=
*cite journal | author=Zazzeroni F, Papa S, Algeciras-Schimnich A, "et al." |title=Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. |journal=Blood |volume=102 |issue= 9 |pages= 3270–9 |year= 2004 |pmid= 12855571 |doi= 10.1182/blood-2003-03-0689
*cite journal | author=Major MB, Jones DA |title=Identification of a gadd45beta 3' enhancer that mediates SMAD3- and SMAD4-dependent transcriptional induction by transforming growth factor beta. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5278–87 |year= 2004 |pmid= 14630914 |doi= 10.1074/jbc.M311517200
*cite journal | author=Papa S, Zazzeroni F, Bubici C, "et al." |title=Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 146–53 |year= 2004 |pmid= 14743220 |doi= 10.1038/ncb1093
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399

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