GADD45G

Growth arrest and DNA-damage-inducible, gamma, also known as GADD45G, is a human gene.cite web | title = Entrez Gene: GADD45G growth arrest and DNA-damage-inducible, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10912| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.cite web | title = Entrez Gene: GADD45G growth arrest and DNA-damage-inducible, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10912| accessdate = ]

ee also

*Gadd45

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Beadling C, Johnson KW, Smith KA |title=Isolation of interleukin 2-induced immediate-early genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 7 |pages= 2719–23 |year= 1993 |pmid= 7681987 |doi=
*cite journal | author=Takekawa M, Saito H |title=A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. |journal=Cell |volume=95 |issue= 4 |pages= 521–30 |year= 1998 |pmid= 9827804 |doi=
*cite journal | author=Nakayama K, Hara T, Hibi M, "et al." |title=A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24766–72 |year= 1999 |pmid= 10455148 |doi=
*cite journal | author=Zhang W, Bae I, Krishnaraju K, "et al." |title=CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. |journal=Oncogene |volume=18 |issue= 35 |pages= 4899–907 |year= 1999 |pmid= 10490824 |doi= 10.1038/sj.onc.1202885
*cite journal | author=Suzuki M, Watanabe TK, Fujiwara T, "et al." |title=Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118. |journal=J. Hum. Genet. |volume=44 |issue= 5 |pages= 300–3 |year= 1999 |pmid= 10496071 |doi=
*cite journal | author=Fan W, Richter G, Cereseto A, "et al." |title=Cytokine response gene 6 induces p21 and regulates both cell growth and arrest. |journal=Oncogene |volume=18 |issue= 47 |pages= 6573–82 |year= 2000 |pmid= 10597261 |doi= 10.1038/sj.onc.1203054
*cite journal | author=Gong R, Yu L, Zhang H, "et al." |title=Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1-2 |pages= 95–6 |year= 2000 |pmid= 10773677 |doi=
*cite journal | author=Yi YW, Kim D, Jung N, "et al." |title=Gadd45 family proteins are coactivators of nuclear hormone receptors. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 1 |pages= 193–8 |year= 2000 |pmid= 10872826 |doi=
*cite journal | author=Yang Q, Manicone A, Coursen JD, "et al." |title=Identification of a functional domain in a GADD45-mediated G2/M checkpoint. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 36892–8 |year= 2001 |pmid= 10973963 |doi= 10.1074/jbc.M005319200
*cite journal | author=Azam N, Vairapandi M, Zhang W, "et al." |title=Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2766–74 |year= 2001 |pmid= 11022036 |doi= 10.1074/jbc.M005626200
*cite journal | author=Wan Y, Wang Z, Shao Y, "et al." |title=UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo. |journal=Int. J. Mol. Med. |volume=6 |issue= 6 |pages= 683–8 |year= 2001 |pmid= 11078829 |doi=
*cite journal | author=Kovalsky O, Lung FD, Roller PP, Fornace AJ |title=Oligomerization of human Gadd45a protein. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39330–9 |year= 2001 |pmid= 11498536 |doi= 10.1074/jbc.M105115200
*cite journal | author=Zhang X, Sun H, Danila DC, "et al." |title=Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 3 |pages= 1262–7 |year= 2002 |pmid= 11889197 |doi=
*cite journal | author=Vairapandi M, Balliet AG, Hoffman B, Liebermann DA |title=GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. |journal=J. Cell. Physiol. |volume=192 |issue= 3 |pages= 327–38 |year= 2002 |pmid= 12124778 |doi= 10.1002/jcp.10140
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chung HK, Yi YW, Jung NC, "et al." |title=CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28079–88 |year= 2003 |pmid= 12716909 |doi= 10.1074/jbc.M212835200
*cite journal | author=Sun L, Gong R, Wan B, "et al." |title=GADD45gamma, down-regulated in 65% hepatocellular carcinoma (HCC) from 23 chinese patients, inhibits cell growth and induces cell cycle G2/M arrest for hepatoma Hep-G2 cell lines. |journal=Mol. Biol. Rep. |volume=30 |issue= 4 |pages= 249–53 |year= 2004 |pmid= 14672412 |doi=
*cite journal | author=Jiang F, Wang Z |title=Gadd45gamma is androgen-responsive and growth-inhibitory in prostate cancer cells. |journal=Mol. Cell. Endocrinol. |volume=213 |issue= 2 |pages= 121–9 |year= 2004 |pmid= 15062559 |doi= 10.1016/j.mce.2003.10.050
*cite journal | author=Zerbini LF, Wang Y, Czibere A, "et al." |title=NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 37 |pages= 13618–23 |year= 2004 |pmid= 15353598 |doi= 10.1073/pnas.0402069101
*cite journal | author=Goehler H, Lalowski M, Stelzl U, "et al." |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes